Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 30 n° 340

SetPoint Medical Reports Positive Long-term Results from its Clinical Study of Bioelectronic Medicine to Treat Rheumatoid Arthritis

Posted by fidest press agency su venerdì, 22 giugno 2018

SetPoint Medical, a clinical-stage biomedical technology company developing bioelectronic therapy for chronic inflammatory diseases, announced positive long-term data for its first-in-human study using bioelectronic medicine for rheumatoid arthritis (RA). Building on the positive 3-month results that were published in Proceedings of the National Academy of Sciences (PNAS) in 2016, the follow-up through 24 months demonstrated significant, sustained improvement in clinical disease activity scores and disability indices on bioelectronic therapy. The results were presented in a poster session at the Annual European Congress of Rheumatology (EULAR).
Rheumatoid arthritis is a chronic inflammatory disease that affects 1.5 million people in the United States and costs tens of billions of dollars annually to treat. SetPoint is developing a novel bioelectronic medicine platform that stimulates the inflammatory reflex with digital doses of electricity to produce a systemic anti-inflammatory effect.
In this European study, 17 subjects with moderate to severe RA symptoms were implanted with a vagus nerve stimulating device. Early results demonstrated that bioelectronic therapy significantly reduced rheumatoid arthritis symptoms and inhibited cytokine production at three months. Following completion of primary study timepoint, participants had the option of continuing in the follow-up study, and all chose to continue their treatment.All 17 subjects remained on therapy for 24 months. At the 24-month time point, 87% of the subjects reported had clinically meaningful responses by standard EULAR criteria, demonstrating that bioelectronic medicine has the potential to substantially reduce both clinical RA disease activity and patient disability for two years, with no unexpected safety issues. These improvements were maintained in patients with and without concurrent use of biologic agents.“Long-term clinical efficacy is important in the development of cost-effective therapy, and we are pleased to report long-term durability of bioelectronic medicine in RA, with safe and efficacious results that have been maintained for two years,” said Anthony Arnold, Chief Executive Officer of SetPoint Medical.
SetPoint recently initiated a pilot trial evaluating the company’s proprietary device for treatment of drug-refractory RA patients in the U.S.

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