Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 33 n° 335

New research reveals 4.8% of the UK population have elevated liver iron

Posted by fidest press agency su lunedì, 24 dicembre 2018

The study, conducted by the University of Westminster and Perspectum Diagnostics, used MRI to non-invasively assess levels of liver iron. The numbers of individuals with abnormal levels for two key risk factors of significant liver disease are considerable and represent potentially 2 million NHS patients. The UK health system is under-prepared for the current liver disease epidemic.Iron overload is traditionally associated with genetic disorders such as hereditary haemochromatosis (HH) or as a results of repeated blood transfusions. However elevated levels of liver iron are now often associated with metabolic diseases including insulin resistance, type 2 diabetes and NAFLD. Elevated liver iron is associated with the development of fibrosis and cirrhosis and thought to be involved in the progression from fibrosis to liver cancer.Diagnostic pathways for liver iron currently rely on simple blood tests, which often miss early stages of iron accumulation, and liver biopsy. However, ferritin levels can be influenced by liver damage and inflammation, and in many cases do not correlate well with liver iron stores. Therefore, the development of robust, widely available and non-invasive techniques for the measurement of liver iron are needed. This study used the quantitative MRI behind LiverMultiScan to safely and painlessly assess liver health.Haemochromatosis UK, the national charity representing patients with iron overload, have recently launched an awareness campaign in the House of Commons, and received support from the UK government, the National Consortium of Intelligent Medical Imaging, and GE Healthcare and Perspectum Diagnostics, to improve the availability of MRI scanners with LiverMultiScan and automated image processing to identify NHS patients with iron overload.

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