Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 34 n° 316

Nimbus Therapeutics and Celgene Expand Alliance to Immunotherapy in Oncology

Posted by fidest press agency su giovedì, 11 luglio 2019

Nimbus Therapeutics, a biotechnology company applying deep computational expertise throughout drug discovery and development, today announced the expansion of its long-term strategic alliance with Celgene Corporation to include Nimbus’ HPK1 inhibitor program.
Under the terms of the agreement, Celgene will receive an option to acquire the program up through a clinical inflection point. Nimbus will retain full control of research and development activities for the program prior to the program’s option point. Financial terms will remain undisclosed until Celgene exercises its option to acquire the program.
Hematopoietic Progenitor Kinase 1 (HPK1), a member of the MAP4K family, is an intracellular negative regulator of T cell proliferation and signaling and plays a key role in dendritic cell activation. The challenge with HPK1 thus far has been the ability of small molecules to achieve potency and selectivity profiles that do not inhibit other T cell kinases or MAP4K family members. Given its role in both T cells and dendritic cells, and an opportunity for working synergistically in upregulating immune system surveillance of cancer, HPK1 has been a highly prized target in immuno-oncology. Nimbus will continue to own and develop its potent small molecule HPK1 inhibitors that are highly selective against relevant off targets and possess robust cellular activity.

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