Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 31 n° 301

Clinical Programs in Prostate and Ovarian Cancers at the ESMO Congress 2019

Posted by fidest press agency su lunedì, 16 settembre 2019

Clovis Oncology, Inc. (NASDAQ: CLVS) today announced that three posters highlighting studies from the Rubraca® (rucaparib) clinical development program will be presented at the ESMO (European Society for Medical Oncology) Congress 2019, September 27 – October 1, 2019, in Barcelona, Spain.The accepted abstracts summarize clinical trials in which Rubraca is being evaluated as a single agent in advanced ovarian and prostate cancers. These posters include updated results from the ongoing Phase 2 TRITON2 clinical trial of Rubraca in advanced mCRPC and additional analyses of data from the Study 10, ARIEL2 and ARIEL3 clinical trials in advanced ovarian cancer, which evaluated safety and efficacy in the treatment and maintenance settings.
The data from the TRITON2 trial will be presented in a poster by Professor Ray McDermott, Consultant Medical Oncologist, Tallaght University Hospital and Cancer Trials Ireland, and have been selected for inclusion in a poster discussion session on Sunday, September 29. TRITON2 is an ongoing international, multicenter, open-label, Phase 2 trial of Rubraca in men with advanced prostate cancer with a deleterious BRCA gene mutation (germline or somatic) or deleterious mutation in other homologous recombination repair genes in the metastatic castration-resistant setting.In October 2018, Clovis Oncology announced that the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy designation for Rubraca for the treatment of adult patients with BRCA1/2-mutated mCRPC who have received at least one prior androgen receptor-directed therapy and taxane-based chemotherapy.Additional analyses of data from the Study 10, ARIEL2 and ARIEL3 clinical trials, which supported the European Union (EU) and FDA approvals of Rubraca for women with advanced ovarian cancer in the treatment and maintenance settings, will also be presented.

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