Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 32 n° 312

ProMIS Neurosciences Identifies Novel Antibody Candidates for Multiple System Atrophy

Posted by fidest press agency su giovedì, 10 ottobre 2019

TORONTO and CAMBRIDGE, Mass., Oct. 08, 2019 (GLOBE NEWSWIRE) — ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, has identified several novel antibody candidates for Multiple System Atrophy (MSA), a severe, Parkinson’s-like disease caused by toxic, misfolded forms of the protein alpha-synuclein. The new antibody candidates join ProMIS’ strong pipeline of antibodies that demonstrate high selectivity for toxic misfolded proteins, implicated as a root cause of several neurodegenerative diseases, including Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS).Our preclinical in vitro studies indicate that antibody candidates targeting toxic forms of alpha-synuclein bind strongly to toxic alpha-synuclein aggregates derived from MSA-affected brain. The same antibodies protect cultured neurons from alpha-synuclein toxicity and spreading (propagation). MSA is a rare, progressive disorder caused by loss of nerve cells in the brain; it affects approximately15,000 people in the United States. Scientific studies indicate that toxic oligomers and small soluble fibrils, derived from naturally occurring alpha-synuclein, are a root cause of disease development and progression in MSA. No disease-modifying treatments exist in part because traditional drug development methods are unable to generate antibodies that can target with precision the neurotoxic forms of alpha-synuclein. The ProMIS platform is a novel, proprietary method for discovering and developing antibodies that can uniquely and precisely target highly toxic misfolded proteins, also called toxic oligomers or prions, while preserving normal forms of the protein and normal protein function. The platform not only generates high-quality antibody candidates but also delivers powerful, validated candidates in months versus years.


Inserisci i tuoi dati qui sotto o clicca su un'icona per effettuare l'accesso:

Logo di

Stai commentando usando il tuo account Chiudi sessione /  Modifica )

Google photo

Stai commentando usando il tuo account Google. Chiudi sessione /  Modifica )

Foto Twitter

Stai commentando usando il tuo account Twitter. Chiudi sessione /  Modifica )

Foto di Facebook

Stai commentando usando il tuo account Facebook. Chiudi sessione /  Modifica )

Connessione a %s...

%d blogger hanno fatto clic su Mi Piace per questo: