Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 31 n° 321

American Society for Human Genetics 2019 Annual Meeting

Posted by fidest press agency su venerdì, 18 ottobre 2019

Twist Bioscience Corporation (NASDAQ: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, announced the presentation of new customer, company and collaborator data using the Twist Bioscience target enrichment and library preparation products for next-generation sequencing (NGS). In addition, Twist Bioscience will showcase the results of adding formalin-fixed paraffin-embedded (FFPE) and saliva sample preparation workflows with its NGS products, resulting in uniform sequence coverage of the target area of interest within the genome.
The company also released new data combining sample preparation solutions integrated with the Twist Bioscience library preparation and target enrichment workflow, as well as a new fixed custom panel to conduct target enrichment of the mitochondrial DNA. Library construction for NGS using FFPE samples offers unique challenges in acquiring high-quality sequencing data due to wide distribution of sample quality. Differences in formalin fixation methods, storage conditions, and age lead to crosslinked and/or degraded nucleic acid and inconsistent extraction yields. Therefore, FFPE extraction and library construction methods must be carefully considered for target enrichment applications. In collaboration, Covaris and Twist Bioscience demonstrate a complete library preparation and target enrichment solution that generates ready-to-sequence multiplexed libraries directly from FFPE tissue of various qualities. Specifically, the truXTRAC kit and adaptive focused acoustics (AFA) technology from Covaris generate size specific DNA libraries from FFPE samples that, when paired with Twist Bioscience’s Library Preparation and Human Core Exome Kit, deliver multiplexed libraries for high performance targeted sequencing.

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