Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 31 n° 321

First International Symposium on Merkel Cell Carcinoma 2019

Posted by fidest press agency su lunedì, 21 ottobre 2019

Immunomic Therapeutics, Inc. will present data on its investigational nucleic acid platform, UNITE (UNiversal Intracellular Targeted Expression), that elicits potent immune responses when used with its investigational UNITE vaccine, ITI-3000, in mice. UNITE fuses a tumor-associated antigen, in this case a mutated form of the large T antigen (LT) of Merkel cell polyomavirus (MCPyV), with lysosomal-associated membrane protein 1 (LAMP1). This lysosomal targeting technology results in enhanced antigen presentation and a balanced T cell response, as ITI-3000 activated antigen-specific CD4+ T cells in vivo. The data will be presented at the First International Symposium on Merkel Cell Carcinoma in Tampa, Florida.The majority of Merkel cell carcinomas (MCC) are associated with MCPyV infection, making LT an attractive target for therapeutic cancer vaccines. MCPyV integrates into the host genome, resulting in expression of a truncated form of the viral LT in infected cells. While induction of tumor-reactive CD8+ T cells is a major goal of cancer therapy, CD4+ T cells provide essential support to CD8+ T cells by promoting their expression of cytotoxic effector molecules and increasing their migratory capacity. Cytokines secreted by CD4+ T cells, such as IFNγ, can also exert desirable effects on the tumor microenvironment. Hence, a cancer vaccine that promotes potent, antigen-specific CD4+ T cell responses to MCPyV-LT may drive robust anti-tumor immune responses.

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