Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 34 n° 151

O. Roep, Ph.D., Advances Personalized Medicine for Children With Type 1 Diabetes

Posted by fidest press agency su martedì, 26 novembre 2019

As science continues to advance understanding how diseases like cancer and diabetes operate in the human body, the models for treatment have increasingly moved away from one-size-fits-all approaches and toward more individualized therapies.Led by Bart O. Roep, Ph.D., the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes at City of Hope and director of The Wanek Family Project for Type 1 Diabetes, a new study characterizes how immune responses to type 1 diabetes (T1D) differ among individuals much more than previously thought. The study characterizes those differences in children with T1D, which represents an important first step toward personalized medicine for this patient population.Published in Diabetologia, the journal of the European Association for the Study of Diabetes, Roep and his colleagues found that children with T1D do differ in their islet autoimmune signatures, or how they respond to immune intervention therapies. But rather than many shades of grey, they only saw three subgroups: children who respond to all islet proteins, those who respond to none, and those who only responding to two or three proteins.T1D results from the destruction of insulin-making beta cells by the body’s own immune system. Treatments rely on protecting cells called islets — which contain the insulin producing beta cells — from inflammatory attacks, but immune responses vary.Collectively, the data provided by the study give new insights into type 1 diabetes disease heterogeneity, or complexity, and highlights the importance of grouping patients on the basis of their genetic and autoimmune signatures for immunotherapy and personalized disease management.


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