Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 33 n° 244

Akili Technology Improves Cognitive Impairments in Adults with Major Depressive Disorder

Posted by fidest press agency su lunedì, 16 dicembre 2019

Akili Interactive (“Akili” or “Company”), today announced results of its randomized, controlled study of digital therapeutic AKL-T03 as a treatment for cognitive impairments adjunct to anti-depressant medication in adults with MDD. AKL-T03 demonstrated a statistically significant improvement in sustained attention compared to control. Results of the study were presented yesterday at the 58th Annual Meeting of the American College of Neuropsychopharmacology (ACNP). Cognitive impairment is a fundamental diagnostic criterion of depression, and the majority of people living with MDD experience substantial cognitive issues, including with attention, decision-making and processing speed. Such cognitive impairments have been shown to be a predictor of daily function. More than 16 million people are living with MDD, and a majority have cognitive deficits on neuropsychological tests and/or self-report cognitive issues, yet their options for treatment are limited. AKL-T03 is designed to improve specific cognitive functions and may play a complementary role to antidepressants in the holistic treatment of MDD. AKL-T03 was built on Akili’s SSME technology engine, which deploys sensory and motor stimuli to target and activate the fronto-parietal network in the brain, known to play a key role in cognitive function. The treatment is delivered through a captivating action video game to drive enjoyment and compliance.
In the study, AKL-T03 showed a statistically significant improvement in sustained attention compared to control (p=0.002) on the predefined primary endpoint, as measured by the Test of Variables of Attention (T.O.V.A.®), an FDA-cleared objective measure of attention. Engagement with AKL-T03 also showed a strong correlation with improved processing speed. AKL-T03 was shown to be safe in this study, with no serious adverse events observed. Results of the study will be submitted for publication in a peer-reviewed journal.

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