Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 33 n° 244

Posts Tagged ‘antibody’

Abveris and TetraGenetics Announce Antibody Discovery Collaboration

Posted by fidest press agency su giovedì, 6 giugno 2019

Abveris, Inc., a leader in contract research antibody discovery, today announced that it has entered into a multi-target agreement with TetraGenetics, Inc. a biopharmaceutical company developing novel antibody therapeutics for ion-channel mediated disorders. Under the terms of the agreement, the companies will leverage their proprietary technologies to discover antibodies against traditionally difficult ion channel targets chosen by TetraGenetics.”We are pleased to be working with TetraGenetics to develop antibodies against some of the most elusive therapeutic targets,” commented Garren Hilow, CEO of Abveris. “The combined benefits of our proprietary hyperimmune platform along with TetraGenetics’ unique ion channel technology provide a significant competitive advantage for discovery of antibodies against this traditionally difficult target class.”
For the collaboration, the TetraGenetics’ TetraExpress platform will be leveraged in combination with the proprietary antibody discovery capabilities of Abveris for the discovery of diverse panels of antibodies with therapeutic potential.“As our newest antibody partner, Abveris brings unique technology and a reputation for excellent execution to our growing list of drug discovery programs,” said Doug Kahn, CEO of TetraGenetics.

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EpimAb Biotherapeutics is Granted US Patent on Core Bispecific Antibody Technology

Posted by fidest press agency su giovedì, 25 aprile 2019

EpimAb Biotherapeutics, an emerging biopharmaceutical company based in Shanghai, announced today that the United States Patent and Trademark Office (USPTO) has granted the U.S. Patent No. 10,266,608 entitled “Fabs-In-Tandem Immunoglobulin and Uses Thereof”. Based on EpimAb’s globally filed first application, this patent broadly covers bispecific antibodies obtained utilizing the company’s FIT-Ig® technology in a composition of matter claim.
“This patent underscores the novelty of EpimAb’s approach in bispecific antibody generation and forms an important foundation of EpimAb’s growing IP portfolio,” said Dr. Chengbin Wu, Founder and CEO of EpimAb Biotherapeutics. “The first granted patent in a major pharmaceutical market like the US therefore represents a significant milestone for EpimAb and takes us another step towards our goal to become a leading innovator in cancer biologics.”EpimAb is developing multiple programs based on its FIT-Ig® platform for the treatment of various cancers. Its most advanced product candidate EMB-01, a cMet/EGFR bispecific with a novel mechanism of action was discovered and rapidly developed to the clinic by EpimAb. It is currently being investigated in a clinical Phase I/II trial in the USA and China. A second FIT-Ig molecule is currently under preclinical development with further molecules following soon, rapidly growing EpimAb’s pipeline of bispecific antibodies.

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Five Prime Presents on Novel B7-H4 Therapeutic Antibody at the 2018 AACR Annual Meeting

Posted by fidest press agency su giovedì, 19 aprile 2018

Five Prime Therapeutics, Inc. (Nasdaq:FPRX), a clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics, announced that an oral presentation featuring FPA150, Five Prime’s first-in-class B7-H4 antibody, was given today at the 2018 AACR Annual Meeting in Chicago. The presentation titled “FPA150: A Recombinant, Afucosylated, Fully Human IgG1 Monoclonal Antibody for the Treatment of Malignancies that Express High Levels of B7-H4” by Charles Kaplan is available at FPA150 is a novel B7-H4 antibody that possesses both T cell immune checkpoint blockade and antibody-dependent cellular cytotoxicity (ADCC) activities. FPA150 demonstrates dose-dependent anti-tumor activity in vivo as a monotherapy and elicits complete tumor regressions in preclinical tumor models when given in combination with PD-1 blockade. Five Prime is currently studying FPA150 in a Phase 1 monotherapy trial in patients with solid tumors that overexpress B7-H4.“Our monoclonal B7-H4 antibody, FPA150, appears to possess both T cell checkpoint blockade activity and enhanced ADCC,” said Bryan Irving, Ph.D., Senior Vice President of Research, at Five Prime. “We are studying FPA150 in patients whose tumors overexpress B7-H4 and in which there is high unmet need for immuno-oncology treatments, such as in breast, ovarian and endometrial cancer. Based on the therapeutic properties of FPA150, we believe that this agent has the potential to be an effective therapeutic by improving anti-tumor immune responses in cancer patients.” B7-H4 is a member of the B7-family of T cell immune checkpoint ligands and shares significant homology with other family members, including PD-L1 and PD-L2. B7-H4 is expressed in several human tumors such as carcinomas of the bladder, breast, ovary and endometrium, and its expression tends to correlate with poor prognosis. B7-H4 is also a documented T cell immune checkpoint inhibitory ligand capable of directly suppressing T cell responses.In Investigational New Drug (IND)-enabling pharmacokinetics (PK) and toxicity studies, FPA150 demonstrated a suitable PK profile and was generally well tolerated. A B7-H4 immunohistochemistry (IHC) assay is in development for clinical use as a companion diagnostic to help identify the patients who might benefit most from this treatment.Five Prime is studying FPA150 in a Phase 1 monotherapy trial with a dose-escalation phase in patients with solid tumors, followed by dose expansion in pre-specified cohorts in tumor types based on B7-H4 expression levels. The initial targeted tumors are advanced or metastatic breast, ovarian, endometrial and bladder cancers.

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Chugai’s Bispecific Antibody “ERY974”

Posted by fidest press agency su sabato, 7 ottobre 2017

Chugai Pharmaceutical Co., Ltd. (TOKYO: 4519) announced that the preclinical study findings on its original bispecific antibody ERY974, a molecule that binds Glypican-3 and CD3 simultaneously, and that is currently under development as a Phase I clinical study for solid tumors, were published in the online edition of Science Translational Medicine on October 4, 2017. Glypican-3 (GPC3) is a membrane protein that is expressed with high frequency on the cellular membranes of various tumor cells including hepatocellular carcinoma, lung cancer, and gastric cancer. GPC3 is reported to be expressed in various tissues in the fetal stage and play an important role, but is rarely expressed in normal adult tissues. As GPC3 expression is observed through the malignant transformation of cells, GPC3 is thought to be a protein specific to cancer (tumor-associated antigen). ERY974 is a bispecific antibody that binds to both GPC3 on the cancer cell membrane and to CD3, a membrane protein expressed on T cells, a type of lymphocyte. ERY974 is a T cell Redirecting AntiBod(TRAB) created with Chugai’s proprietary antibody engineering technology, and while simultaneously binding to GPC3 and CD3 and directing T cells to cancer cells, it also activates T cells, specifically attacking and killing neighboring cancer cells. Based on this mechanism whereby it activates T cells and attacks cancer cells, TRAB is classified as a type of cancer immunotherapy.
According to the immunohistochemistry, GPC3 is expressed in various cancers (a hepatocellular carcinoma, a squamous lung cancer, a small cell lung cancer, an esophageal cancer, a gastric cancer and a head and neck cancer), and as previously reported, it is rarely expressed in normal tissues (30 different tissues) (in vitro) GPC3-dependent T cell activation and killing of cancer cells by ERY974 was observed in vitro In three different experimental tumor models using mouse, ERY974 demonstrated anti-tumor effects Anti-tumor effects were observed even in cancers where other cancer immunotherapies are ineffective (Mouse) Tolerability of ERY974 was observed in toxicity testing in animal Based on the results of this preclinical study, Chugai began phase I clinical trial of ERY974 in patients with GPC3 positive solid tumors in the United States in August 2016 (NCT02748837). As a leading company in the field of antibody therapeutics, Chugai will continue to contribute to global healthcare and the health of all people through the creation of innovative treatments using its proprietary antibody technologies.

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ESC Congress 2017 Hot Line Tips

Posted by fidest press agency su domenica, 20 agosto 2017

barcellonaBarcelona (Spain) from 26 to 30 August at the Fira Barcelona Get ready for the most highly anticipated cardiovascular science of the year in the ESC Congress 2017 Hot Line – Late Breaking Clinical Trials.
The primary results of these novel clinical trials will be presented, with findings revealed in advance to the media in six dedicated press conferences.Be the first to hear the results of CANTOS, designed to directly test the inflammatory hypothesis of atherothrombosis by randomly allocating post-myocardial infarction patients to one of three doses of canakinumab (a monoclonal antibody targeting interleukin 1-beta) or to placebo.Is giving oxygen to patients with myocardial infarction useful, or can it actually do harm? Learn more about the role of oxygen in suspected acute myocardial infarction from DETO2X-AMI, a registry-based randomised clinical trial done in 35 hospitals across Sweden.Is aspirin enough in secondary prevention? Find out the primary results of COMPASS, which assessed whether rivaroxaban, either alone or with aspirin, is superior to aspirin alone for the prevention of myocardial infarction, stroke, and cardiovascular death in patients with stable coronary or peripheral artery disease.Can we rely on oral anticoagulants in the context of electrical cardioversion? EMANATE will focus on apixaban versus conventional therapy in anticoagulation-naive patients with atrial fibrillation undergoing cardioversion.
Protection of the brain during open heart surgery is explored in the LAACS study. This randomised study examined whether surgical closure of the left atrial appendage during open heart surgery protects the brain against thromboembolic damage.Results of the VIVA trial will reveal the mortality impact and cost-effectiveness of combined screening for abdominal aortic aneurysm, peripheral artery disease and hypertension.
The impact of single or multiple injections of the first-in-class PCSK9 inhibitor inclirisan on low-density lipoprotein (“bad”) cholesterol will be presented in the phase II ORION 1 trial, which aims to establish the dose and dosing frequency required in phase III trials.A clinical trial update on the FOURIER trial will show the efficacy and safety of evolocumab added to high-intensity or moderate-intensity statin therapy in patients with clinically evident atherosclerotic cardiovascular disease. PURE will reveal the dose-response effect of fruit, vegetable and legume intake on cardiovascular disease and mortality among 135 335 individuals aged 35 to 70 years without prior cardiovascular disease from 18 countries on five continents.
Findings from the prospective international longitudinal registry CLARIFY of 32 703 outpatients with stable coronary artery disease will explain how low diastolic blood pressure and increased pulse pressure contribute to the J curve in hypertensive patients with coronary artery disease.This is just a small taste of the groundbreaking research that will be presented in this year’s programme of late-breaking science, which includes 21 Late Breaking Clinical Trials, presented and discussed in four Hot Line sessions, plus late breaking results from 12 registries and 12 Clinical Trial Updates.

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