Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 31 n° 259

Posts Tagged ‘candidates’

Verastem Oncology to Present Data on Two Lead Drug Candidates at ASCO 2018 Annual Meeting

Posted by fidest press agency su lunedì, 21 maggio 2018

Chicago Verastem, Inc. (Nasdaq: VSTM) (Verastem Oncology or the Company), a biopharmaceutical company focused on developing and commercializing medicines to improve the survival and quality of life of cancer patients, today announced that five abstracts have been selected for poster presentations at the 54th Annual Meeting of the American Society of Clinical Oncology (ASCO) being held June 1-5, 2018 in Chicago. The Company will present data on its lead product candidate, duvelisib, a first-in-class oral dual inhibitor of phosphoinositide 3-kinase (PI3K)-delta and PI3K-gamma, as well as defactinib, its oral small molecule inhibitor of Focal Adhesion Kinase (FAK). The poster presentations will highlight the latest findings from the Company’s ongoing clinical trials for duvelisib, the Phase 3 DUO study crossover extension in patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), in addition to a Phase 1 study of defactinib in combination with pembrolizumab and gemcitabine in patients with relapsed/refractory pancreatic cancer. A poster will also be presented on PRIMO, a Phase II study that Verastem Oncology has initiated to evaluate duvelisib monotherapy in peripheral T-cell lymphoma (PTCL), one of the most aggressive forms of non-Hodgkin lymphoma (NHL). The U.S. Food and Drug Administration (FDA) has granted fast track designation to the investigation of duvelisib for the potential treatment of patients with peripheral T-cell lymphoma (PTCL) who have received at least one prior therapy. This study was initiated based on promising activity observed with duvelisib monotherapy in T-cell lymphomas in the Phase I study. In addition, posters on biomarker measurements in the DUOTM and DYNAMOTM studies, as well as in a treatment naive follicular lymphoma study, will be presented.“In the crossover extension trial of the Phase 3 DUO study, patients treated with duvelisib following confirmed disease progression on prior ofatumumab therapy exhibited a 73% overall response rate (ORR), compared to a 28% ORR with ofatumumab in the DUO study. These results were consistent with the ORR of patients originally initiated on duvelisib. This response rate was accompanied by a longer median progression-free survival (mPFS), with duvelisib-treated patients achieving 15-month mPFS, compared to 9 months when they were treated with ofatumumab,” said Diep Le, MD, PhD, Chief Medical Officer of Verastem Oncology.Dr. Le added, “For our lead FAK inhibitor defactinib, Dr. Andrea Wang-Gillam will describe initial results from the ongoing Phase 1 study evaluating defactinib in combination with pembrolizumab and gemcitabine in patients with advanced pancreatic cancer. In addition to defining a recommended Phase 2 dose, the combination regimen has been well tolerated with promising signs of clinical activity, including one confirmed partial response in a pancreatic cancer patient and stable disease in additional pancreatic patients.” “Data presented at this year’s ASCO meeting by Verastem Oncology and collaborative researchers also directly demonstrate inhibition of both PI3K-delta and PI3K-gamma in patients treated with duvelisib,” said Jonathan Pachter, PhD, Chief Scientific Officer of Verastem Oncology. “Accordingly, biomarker changes observed in duvelisib-treated patients indicate targeting of malignant B-cells directly along with targeting of the supportive tumor microenvironment.”

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Candidates wanted by business school

Posted by fidest press agency su venerdì, 16 aprile 2010

Two new scholarships, designed to aid MBA candidates from non-traditional academic backgrounds, are being offered by QS World MBA Tour and The European School of Management and Technology (ESMT)  •    €25,000 for each scholarship winner. With more candidates than ever taking GMAT in 2009 and a drop in loan availability as a result of the economic crisis, QS World MBA Tour brings new opportunities for international candidates wishing to join the world’s leading business schools. The most recent additions to the $1,600,000 QS Scholarship Fund are two scholarships from ESMT, Germany, aimed towards MBA candidates from non-traditional academic backgrounds. The scholarships, valued at €25,000 each are available to candidates who have attended a QS World MBA Tour in Spring or Fall 2010, completed the QS applicant survey and have been granted admittance to the ESMT Berlin MBA program. Nick Barnville, Program Director at ESMT, says “These exclusive scholarships are a great tool to reach the international candidates we meet at the World MBA Tour fairs around the world.  We aim to be the first school in Europe to have 50% women on the MBA, and are specifically targeting participants from non-traditional backgrounds, such as medicine or the creative arts. It is often the case that many applicants from these backgrounds face specific financial challenges.” Candidates are required to have at least three years’ work experience and have submitted an essay on the topic “Describe one event from your professional life where you challenged mainstream thought in a group setting, and describe the outcome, positive or negative” Candidates need to apply by 30th April 2010 via http://www.topmba.com/finance/apply-mba-scholarships

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