Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 31 n° 275

Posts Tagged ‘cardiovascular’

The “Cardiovascular Drug Delivery – Technologies, Markets & Companies”

Posted by fidest press agency su giovedì, 15 agosto 2019

The cardiovascular drug delivery markets are estimated for the years 2018 to 2028 on the basis of epidemiology and total markets for cardiovascular therapeutics.The estimates take into consideration the anticipated advances and availability of various technologies, particularly drug delivery devices in the future. Markets for drug-eluting stents are calculated separately. Role of drug delivery in developing cardiovascular markets is defined and unmet needs in cardiovascular drug delivery technologies are identified.
Drug delivery to the cardiovascular system is different from delivery to other systems because of the anatomy and physiology of the vascular system; it supplies blood and nutrients to all organs of the body. Drugs can be introduced into the vascular system for systemic effects or targeted to an organ via the regional blood supply. In addition to the usual formulations of drugs such as controlled release, devices are used as well. This report starts with an introduction to molecular cardiology and discusses its relationship to biotechnology and drug delivery systems.Drug delivery to the cardiovascular system is approached at three levels: (1) routes of drug delivery; (2) formulations; and finally (3) applications to various diseases. Formulations for drug delivery to the cardiovascular system range from controlled release preparations to delivery of proteins and peptides. Cell and gene therapies, including antisense and RNA interference, are described in full chapters as they are the most innovative methods of delivery of therapeutics. Various methods of improving systemic administration of drugs for cardiovascular disorders are described including use of nanotechnology.Cell-selective targeted drug delivery has emerged as one of the most significant areas of biomedical engineering research, to optimize the therapeutic efficacy of a drug by strictly localizing its pharmacological activity to a pathophysiologically relevant tissue system. These concepts have been applied to targeted drug delivery to the cardiovascular system. Devices for drug delivery to the cardiovascular system are also described.Role of drug delivery in various cardiovascular disorders such as myocardial ischemia, hypertension and hypercholesterolemia is discussed. Cardioprotection is also discussed. Some of the preparations and technologies are also applicable to peripheral arterial diseases. Controlled release systems are based on chronopharmacology, which deals with the effects of circadian biological rhythms on drug actions. A full chapter is devoted to drug-eluting stents as a treatment for restenosis following stenting of coronary arteries. Fifteen companies are involved in drug-eluting stents.Selected 82 companies that either develop technologies for drug delivery to the cardiovascular system or products using these technologies are profiled and 80 collaborations between companies are tabulated. The bibliography includes 200 selected references from recent literature on this topic. The report is supplemented with 31 tables and 9 figures.

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ESC: Providing Asian doctors with the Very Latest in Cardiovascular Science

Posted by fidest press agency su sabato, 20 luglio 2019

8 to 10 November in Singapore. How can physicians in Asia keep abreast of so many rapidly evolving advances in heart health? A new scientific congress is designed to help.
The European Society of Cardiology (ESC), the world’s largest organisation of healthcare professionals dedicated to fighting heart disease, is joining forces with the Asian Pacific Society of Cardiology (APSC) and the Asean Federation of Cardiology (AFC) to launch ESC ASIA with APSC & ASC in Singapore this November.“Each year, the ESC alone reviews more than 11,000 abstracts on new cardiovascular science,” said Prof. Michel Komajda, Chair of the Organising Committee. “This new congress will showcase the very latest, most important lessons so that physicians can provide their heart patients with the best possible care.”This cutting-edge event will help explain the new, all important ESC Clinical Practice Guidelines on Diabetes, Pre-diabetes & Cardiovascular Diseases; Acute Pulmonary Embolism; Chronic Coronary Syndromes; and Dyslipidaemias. In addition, many of the key messages from ESC Congress 2019 in Paris will also be discussed in an Asian Pacific context.
This new congress could not be more timely. According to the World Health Organisation, cardiovascular disease is world’s leading cause of death, killing an estimated 31% of all people. 1 In Singapore alone, it claims 21,000 lives every year. This pioneering event builds on ESC’s reputation in the region as a renowned and trusted learned society. Tens of thousands of healthcare professionals in Asia already turn to the ESC for its prestigious journals, scientific congresses and a variety of unique membership opportunities.“The ESC is the only global society that covers the full spectrum of cardiology through its many subspecialty communities in Asia,” said Prof. Komajda. “This new event offers physicians of all sorts – from internists and endocrinologists to pulmonologists and cardiologists – the opportunity to exchange ideas with some the most respected cardiovascular researchers from Europe and the Asia Pacific region.”

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Reprieve Cardiovascular Announces Late-Breaking Acute Heart Failure Clinical Trial Data

Posted by fidest press agency su lunedì, 27 maggio 2019

Reprieve Cardiovascular™, a pioneering medical device company focused on improving outcomes for patients suffering from Acute Decompensated Heart Failure (ADHF), today announced the results of two non-randomized, prospective clinical trials in patients hospitalized with Acute Heart Failure (AHF). The two studies demonstrate that using Reprieve-Guided Diuretic Therapy, the first fully automated fluid management system, allows for safe decongestion for patients with AHF. The results were presented today at the Heart Failure 2019 Congress, 25-28 May, in Athens, Greece.The 19-patient TARGET-1 and TARGET-2 clinical trials were designed to determine whether the Reprieve-Guided Diuretic Therapy system could achieve safe net volume reduction while significantly alleviating related symptoms in ADHF patientsThe data reported a significant increase in diuresis, net negative fluid balance, improved kidney function and improvement in clinical symptoms.Patients served as their own controls with each patient undergoing 24 hours of standard diuretic therapy with intravenous furosemide followed by 24 hours of diuresis with the automated Reprieve-Guided System. The average urine output increased from 1986 ml in the standard therapy to 6284 ml during a 24-hour therapy period. In addition, there were improvements in net fluid loss, and renal function accompanied by favorable hemodynamic changes.“The therapy appears to be safe and quite effective,” said Professor Piotr Ponikowski, Professor of Cardiology at Wroclaw Medical University, Poland. “Reprieve’s automated fluid management technology provided faster, more controlled fluid removal while protecting acute heart failure patients from dangerous drops in blood pressure. It maintained optimal intravascular fluid volume and with it, cardiac output and renal perfusion.” ADHF is a sudden onset of heart failure symptoms, which typically include difficulty breathing (dyspnea), swelling in the extremities, and fatigue. The signs and symptoms of fluid overload are responsible for 90% of heart failure hospital admissions. Current treatment for ADHF includes diuretic therapy that aims to restore healthy fluid levels in the kidneys and throughout the body. Standard diuretic therapy, however, can be unpredictable and lose effectiveness as a patient’s condition deteriorates. In some patients, diuretics can trigger a condition called “diuretic resistance,” which blunts the function of diuretics and can exacerbate the severity of fluid overload, potentially resulting in acute kidney injury.

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Cardiovascular Surgery Detailing Preclinical and Clinical Evaluation of SETALIUMTM Vascular Sealant

Posted by fidest press agency su sabato, 18 maggio 2019

TISSIUM, a privately-owned life science company developing fully synthetic, biomorphic programmable polymers, announced today the publication of its manuscript detailing preclinical and clinical evaluations of SETALIUMTM Vascular Sealant, the company’s first synthetic, biodegradable, on-demand, light-activated sealant.The results of these evaluations, published in The Journal of Cardiovascular Surgery on May 10th, 2019, ultimately showed that SETALIUM™ Vascular Sealant has good biocompatibility, good bioresorption, and a beneficial safety and efficacy profile.SETALIUMTM Vascular Sealant is a new synthetic on-demand, light-activated poly (glycerol sebacate) acrylate (PGSA), and pre-clinical and clinical studies were designed to assess the biocompatibility of this product, as well as its performance in living subjects. Pre-clinical trials included three successful large animal studies during which open vascular carotid and aortic reconstruction surgeries were performed. With these promising results, clinical trials were initiated in patients requiring carotid endarterectomy using an ePTFE patch.Biocompatibility testing demonstrated that standard clinical doses of the SETALIUMTM Vascular Sealant, and 40 times that dose, did not induce any significant toxic reaction. Animal studies produced excellent performance and safety data.Clinically significant hemostasis was achieved in 100% of the animals across carotid and aorta studies. In clinical studies, immediate hemostasis was achieved in 84% of cases with no device-related adverse events reported.As a result, the SETALIUM™ Vascular Sealant showed good biocompatibility, and an acceptable safety profile. In human trials, it was shown to be a safe and effective option that can achieve fast hemostasis in vascular carotid reconstructions.
TISSIUM is a privately-owned life sciences company based in Paris, France that is dedicated to the rapid development and commercialization of a unique biopolymer platform to address various unmet clinical needs.The company’s platform is based on a proprietary polymer family with unique properties including the ability to conform to, and integrate with, surrounding tissue to enable natural healing. Furthermore, the modular design of the polymers enables customization to match tissue-specific requirements for different therapeutic areas. The company also develops delivery and activation devices for enhanced performance and usability of its family of polymers.

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Researchers discover molecular basis for increased cardiovascular disease in older women

Posted by fidest press agency su sabato, 21 aprile 2018

Vienna, Austria Researchers have discovered the molecular basis for the increased incidence of cardiovascular diseases in older women. The study, which is presented today at Frontiers in CardioVascular Biology (FCVB) 2018, a European Society of Cardiology (ESC) congress found that older women had mitochondrial dysfunction, reduced antioxidant proteins, and increased inflammation. Previous studies have shown sex differences in the age at which cardiovascular diseases occur. Ischaemic heart disease, for example, develops on average seven to ten years later in women compared with men. It occurs three to four times more often in men than in women below the age of 60 years, but after the age of 75, most patients are women. It is not clear why many women are protected from cardiovascular disease at a young age but are more susceptible after menopause. Oestrogen levels may play a role but the mechanism is unknown. This study looked at molecular changes in the cells of the heart that happen with ageing, and how they differ between men and women.Specifically, the researchers looked at healthy hearts to see if there are sex differences in mitochondrial function and inflammation during ageing. Heart tissue was obtained from seven women and seven men aged 17 to 40 years, and from eight women and nine men aged 50 to 68 years. The researchers measured levels of proteins involved in inflammation and in the function of the mitochondria.The researchers found that the levels of Sirt1, a protein which is important for the function of the mitochondria, are higher in young women compared to young men. In the older hearts, Sirt1 levels had decreased in women but not in men. Expression of superoxide dismutase 2, an antioxidant protein in the mitochondria, was higher in young females than males but the difference was no longer present with age.In addition, the expression of catalase, an enzyme that protects cells from oxidative damage, was higher in young females than males but again the difference was lost with age.With age, female hearts shifted from an anti-inflammatory to a pro-inflammatory environment. Compared to young men, young women had higher levels of anti-inflammatory cytokines such as interleukin 10 – but this difference was lost with age. Levels of macrophages, which promote inflammation, increased with age in women but not in men.Dr Maria Luisa Barcena De Arellano, scientific researcher, Institute of Gender Medicine, Charité University Medicine Berlin, Germany, said: “Our study provides a molecular explanation for the increased incidence of cardiovascular diseases in older women.” “We found that the hearts of older women have reduced expression of antioxidant proteins and proteins that are important for mitochondrial function,” she continued. “This may lead to the increased inflammation we observed in older women. Inflammation is known to contribute to cardiovascular disease.”Dr Barcena De Arellano said that in young women, oestrogen may protect or improve the function of the mitochondria and keep inflammation down. She said: “We have previously shown that oestrogen improves the expression of mitochondrial proteins and antioxidant proteins, and decreases oxidative stress. We think that the fall in oestrogen with menopause contributes to mitochondrial dysfunction.”She added that hormone replacement therapy is taken by some women to boost oestrogen levels and reduce the risk of heart disease, but it may not be appropriate for everyone.Dr Barcena De Arellano said: “Our study suggests that a new drug could be developed which increases the expression of mitochondrial proteins. This could improve mitochondrial function, reduce inflammation, and help to prevent cardiovascular disease in older women.”

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CMR 2018 showcases advances in cardiovascular magnetic resonance improving patient care

Posted by fidest press agency su giovedì, 18 gennaio 2018

barcellonaBarcelona, Spain 31 January to 3 February CMR 2018 will showcase the latest advances in cardiovascular magnetic resonance (CMR) and how they are improving patient care and outcomes. CMR 2018 is a joint EuroCMR and SCMR meeting organised by the European Association of Cardiovascular Imaging (EACVI), a registered branch of the European Society of Cardiology, and the Society for Cardiovascular Magnetic Resonance (SCMR).It will be held 31 January to 3 February in Barcelona, Spain, at the Centre Convencions Internacional de Barcelona (CCIB). The scientific programme is available hereThe congress theme ‘improving clinical value by technical advances’ emphasises how new developments in CMR benefit patients. Higher quality images increase understanding of disease and enable better diagnosis and treatment, while faster scan times help reduce waiting lists and provide a better patient experience.CMR has a major role to play in the prevention of sudden cardiac death and will be debated at CMR 2018 by leaders in the fields of imaging and arrhythmias. Professor Josep Brugada, a leading clinical cardiologist and arrhythmia expert based in Barcelona, will give a keynote lecture on the latest developments in ventricular arrhythmias. Other distinguished speakers include ESC President Professor Jeroen Bax.Dr Jose Palomares, CMR 2018 abstract co-chairperson (representing EuroCMR), said: “International clinical and CMR specialists will provide the most up-to-date information in different disease areas. They will also reveal what is on the horizon in terms of furthering our understanding of what causes diseases and how to best diagnosis and treat them.”
Heart disease causes many deaths in women but the way it develops is different to men. In women, heart disease mainly affects the microvessels, making it more difficult to detect. “CMR is particularly well suited to helping us understand heart attacks in women and how to better manage them,” said Dr Allison Hays, CMR 2018 abstract co-chairperson (representing SCMR).Artificial intelligence is a hot topic and will be the focus of a session on deep learning/machine learning. Professor Daniel Rueckert, a leader in machine learning development in magnetic resonance, will join other specialists to discuss how these areas are revolutionising CMR by boosting productivity and expanding the limits of what can be measured. Novel methods will be presented along with technological advances in this rapidly developing field.CMR is increasingly being used to detect metabolic changes in the heart. Specialists will show how imaging detects fat build up in the heart, which can predict who will develop heart failure and arrhythmias and indicate the impact of medications and lifestyle changes.Around 1–2% of adults in developed countries have heart failure but treatments are available and some cases can even be prevented. Novel CMR techniques like T1 mapping are being used for the early detection of fibrosis in the heart to identify patients at risk for heart failure. A number original scientific abstracts will show the latest findings in this field.
Ischaemia imaging is another focus in the abstracts, which show the value of CMR in diagnosing and risk stratifying patients with suspected coronary artery disease in a standardised way. Clinical trial results will be presented showing how CMR can be used cost effectively to improve patient outcomes. A workshop will be held in conjunction with the International Society for Magnetic Resonance in Medicine (ISMRM).Dr Palomares said: “Scientific information is growing exponentially. CMR 2018 brings together leading clinicians and imagers from across the globe to highlight the key developments in cardiovascular magnetic resonance and where the boundaries of science and medicine are being pushed.”Dr Hays said: “The important technical advances and large scale clinical trials in CMR will be presented, making CMR 2018 an event not to be missed. Patient outcomes are a big focus of the conference – we are not just taking pictures of the heart, we are applying it in a clinically meaningful way to improve healthcare.”

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Pneumonia or sepsis in adults associated with increased risk of cardiovascular disease

Posted by fidest press agency su mercoledì, 2 agosto 2017

Sophia Antipolis. Pneumonia or sepsis in adults that results in hospital admission is associated with a six-fold increased risk of cardiovascular disease in the first year, according to research published today in the EuropeanSophia Antipolis Journal of Preventive Cardiology.1 Cardiovascular risk was more than doubled in years two and three after the infection and persisted for at least five years.“Severe infections in adulthood are associated with a contemporaneously raised risk of cardiovascular disease,” said last author Professor Scott Montgomery, director of the clinical epidemiology group, Örebro University, Sweden. “Whether this raised risk persists for several years after infection is less well established.”This study examined if hospital admission for sepsis or pneumonia is associated with an increased risk of cardiovascular disease in the years following infection, and whether there is a period of particularly heightened risk.The study included 236 739 men born between 1952 and 1956 who underwent extensive physical and psychological examinations at around age 18 years as part of compulsory military conscription assessments. The researchers obtained infection and cardiovascular disease diagnoses from a register that has recorded information on patients admitted to hospital since 1964. The men were followed from late adolescence into middle age (follow-up was completed in 2010).During the follow-up period, a total of 46 754 men (19.7%) had a first diagnosis of cardiovascular disease. There were 9 987 hospital admissions for pneumonia or sepsis among 8 534 men who received these diagnoses.The researchers found that infection was associated with a 6.33-fold raised risk of cardiovascular disease during the first year after the infection. In the second and third years following an infection, cardiovascular disease risk remained raised by 2.47 and 2.12 times. Risk decreased with time but was still raised for at least five years after the infection by nearly two–fold (hazard ratio 1.87).Similar findings were observed for coronary heart disease, stroke, and fatal cardiovascular disease. The persistently raised risk could not be explained by subsequent severe infections.“Our results indicate that the risk of cardiovascular disease, including coronary heart disease and stroke, was increased after hospital admission for sepsis or pneumonia,” said lead author Dr Cecilia Bergh, an affiliated researcher at Örebro University. “The risk remained notably raised for three years after infection and was still nearly two-fold after five years.”When the researchers examined the relationship between other risk factors such as high blood pressure, overweight, obesity, poorer physical fitness, and household crowding in childhood, they found that infection was associated with the highest magnitude of cardiovascular disease risk in the first three years post-infection.Professor Montgomery said: “Conventional cardiovascular risk factors are still important but infection may be the primary source of risk for a limited time.”The authors said the results point to a causal relationship, since cardiovascular disease risk is very high immediately after infection and reduces with time. Persistent systemic inflammation after a severe infection may play a role, as inflammation is a risk for cardiovascular disease. Most patients with sepsis or pneumonia recover but many still have high circulating inflammatory markers after the acute phase of the infection.
Professor Montgomery said: “Our findings provide another reason to protect against infection and suggest that there is a post-infection window of increased cardiovascular disease risk. We did not study any interventions that could be initiated during this period, but preventative therapies such as statins could be investigated.”

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Cardiovascular nurses set to discuss how smartphones can improve continuity of care

Posted by fidest press agency su martedì, 18 aprile 2017

Sophia Antipolis. The use of smartphones to assist the continuity of care between hospital and community iSophia Antipoliss set to be discussed at EuroHeartCare 2017, which will be held 18 to 20 May in Jonkoping, Sweden, at the Spira Cultural Centre.
EuroHeartCare is the official annual meeting of the Council on Cardiovascular Nursing and Allied Professions (CCNAP) of the European Society of Cardiology (ESC). This year’s meeting is held in collaboration with the Swedish Association on Cardiovascular Nursing and Allied Professions (VIC).EuroHeartCare is the event to attend for cardiovascular nurses and allied professionals. More than 500 delegates are expected from over 40 countries. During the two-and-a-half day event, members of the press can get the results of cutting edge research from original scientific abstracts and gain insights into topical areas of nursing and cardiovascular care in state-of-the art lectures by renowned experts.
Journalists at the conference will hear about smartphone innovations for patients with cardiovascular disease. “Sophisticated wireless technologies are being developed for many aspects of care in the cardiac patient,” said Dr Gabrielle McKee, programme chair of EuroHeartCare. “Remote ECG and rhythm monitoring have the potential for patients to alert the hospital when arrhythmias or a heart attack occur. These technologies are easy to use, yet safe, efficient and accurate, and should lead to patients responding and receiving treatment more promptly.” “The amount of time patients stay in hospital is much, much shorter than it used to be,” said Dr McKee. “After a major cardiac event we give substantial educational information to patients but the chances are that they don’t take it all in. Smartphone technologies are enabling us to continue to educate patients, to monitor their risk factors and help promote goal setting, behavioural change and self-care in the long-term.”The origins of obesity will be explored by international leaders in a dedicated session. Dr McKee said: “It is thought that when we became farmers instead of hunters and gatherers this increased the risk of famine, and those with the genetic make up to lay down fat survived better. In today’s world, this adaptation plus the fact that we need less than half the calories of our forefathers, and that food has become more varied, appealing and calorific leave us at risk of eating more calories than we expend.” Members of the press will discover how behaviour change can address the obesity crisis. “We need to shift the focus away from just the weighing scales and kilograms towards developing new habits,” said Dr McKee. “For example not rewarding yourself with something to eat when something good happens. At the congress we’ll discuss exciting ways that are helping people to change their behaviour which leads to a healthier lifestyle and subsequent weight loss that can be maintained long term.”The use of mindfulness to improve mental health and wellbeing in cardiac patients is another hot topic. Journalists will get the most up-to-date research findings on this and other mental health strategies such as cognitive behavioural therapy for treating depression in patients with cardiac disease and heart failure.The theme “Team Work for Excellence in Cardiovascular Care” will be featured throughout the congress. A session on how to build a golden team strategy will show journalists how the multidisciplinary team delivers treatment for a heart attack within an hour from the onset of chest pain, referred to as the golden hour. One of the consequences of good health care and innovation is that we are living longer. Frailty is a growing issue that requires team work between cardiology and gerontology and will be discussed in a session on the new challenges in prevention and rehabilitation.Dr McKee said: “There are many challenges in today’s care that mean that team work including cardiologists, surgeons, nurses, physiotherapists and nutritionists is needed to reinforce self-care and prevention messages. This will help patients not only to feel ‘fixed’ after a treatment in hospital but aware and educated with a care plan to help prevent recurrence.”

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ESC on eHealth Revolution: A New Vision For Cardiovascular Medicine

Posted by fidest press agency su venerdì, 24 febbraio 2017

Sophia AntipolisSophia Antipolis. How are smartphones and computer programs transforming healthcare, especially when it comes to preventing, diagnosing and treating heart disease? That’s the focus of a collection of articles published today in the European Heart Journal (EHJ).
Called eHealth, it includes smartphone applications that can predict a patient’s worsening heart failure simply from the sound of a person’s voice, or an app that warns someone walking down a street that blood pressure or glucose levels are dangerously low. There are mobile apps for doctors in the clinic that provide computerised decision support systems.There’s even Big Data that analyses millions of patient records to understand what cardiovascular treatments are having the greatest impact in specific situations, or how the results from one country compare to the results in others.
“Our profession and its use of electronic information is changing rapidly” said Professor Jeroen Bax, president of the European Society of Cardiology (ESC). “Cutting-edge technologies are providing medical insights like never before.”The ESC has representatives working with the European Commission’s Expert groups on eHealth to ensure the interests of cardiovascular professionals and their patients are well represented. The ESC sees eHealth as vital to achieving its mission of reducing the burden of cardiovascular disease and allowing people to live longer, healthier lives.
Professor Martin Cowie, professor of cardiology at the National Health and Lung Institute at Imperial College London, and coordinator of the ESC eHealth Unit, said remote access and personal monitoring would enable heart patients to gather their own data.“eHealth is truly a revolution for health and healthcare. It’s one of the most exciting changes we have seen in decades. It can help empower a person living with a medical condition,” said Professor Cowie. “People don’t have to go to hospital to receive input. They can collect information at home or even when they are out and about pursuing their daily activities and those data can help doctors make better and more timely decisions with them.”
On Big Data, IBM created the cutting-edge technology platform Watson that can help a physician diagnose a medical complaint by combing through more than a million textbooks and scientific abstracts within seconds. “We are a catalyst to translate big data to empower doctors so they can take more time with their patients,” said Dr. Kyu Rhee, chief health officer at IBM.

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Number of children emerging as cardiovascular risk factor for both parents

Posted by fidest press agency su domenica, 5 febbraio 2017

cardiologiaSophia Antipolis Number of children is emerging as a novel factor that influences the risk for some cardiovascular diseases (CVD), and in some societies in both parents, according to Professor Vera Regitz-Zagrosek, chairperson of the European Society of Cardiology “management of CVD During Pregnancy” guidelines task force.Her comments come as new research published in Circulation found that experiencing multiple pregnancies increases a woman’s risk of developing atrial fibrillation (AF) later in life.1. “The authors describe a linear increase in AF with increasing number of children” said Professor Regitz-Zagrosek. “This is interesting by itself and an explanation could be given by biological and sociocultural factors.” A study of 0.5 million Chinese people found a statistically significant J-shaped relationship between number of children and risk of coronary heart disease and stroke.2 “It means that the risk decreases with one child, then increases with two or more children,” she said. “In the AF study, a J-shaped relationship was not statistically significant, but this may be because it was in around 34 000 women and relatively small in comparison with the Chinese study.” “The striking thing was that the Chinese study showed the same association for women and men,” said Professor Regitz-Zagrosek. “In a further study, they demonstrated the same J-shaped association between number of children and risk of diabetes in women and men.” “The authors believe that socioeconomic factors are the explanation,” she continued. “Having one child is protective because parents have social support in older age. But if they have a large number of children this benefit goes away because it increases the economic and social pressure on the parents.” “Number of children should be considered a new factor that may influence the risk for some cardiovascular diseases for women and men and included in research databases to be further investigated as a health indicator,” she added.
Professor Regitz-Zagrosek said further research should investigate biological and socioeconomic mechanisms to explain the relationship between number of children and cardiovascular risk. “There is evidence that pregnancy leads to alterations that change the body’s reaction to additional cardiovascular stressors,” she said, “And this may happen by epigenetic mechanisms. But the findings in Chinese men favour the socioeconomic explanation.” A separate study in Circulation found that delivering a premature baby may be associated with later cardiovascular disease, regardless of other risk factors.4 Researchers reviewed data on 70 182 women in the Nurses’ Health Study II and found that women who deliver a premature baby before 37 weeks gestation in their first birth have a 40% greater risk of later CVD compared to women who deliver at term, and those who deliver before 32 weeks are at twice the risk compared to full-term deliveries.Professor Regitz-Zagrosek said: “I fully agree that preterm delivery is a cardiovascular risk factor for women, just like preeclampsia or gestational diabetes. This study confirms the results of previous research and adds new findings: the increased risk from preterm delivery is not explained by previous lifestyle or coronary artery disease risk factors, and it’s also not accounted for by the development of risk factors after delivery.” “The paper’s weakness is that the only socioeconomic parameter it includes is parental education and we are not told if it is referring to the mother or father,” she added. “Again, socioeconomic mechanisms may be really important in this field.”

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Acute Cardiovascular Care 2016 will put a spotlight on managing high risk patients

Posted by fidest press agency su sabato, 17 settembre 2016

navigatore coronarieThe annual congress of the Acute Cardiovascular Care Association (ACCA), a registered branch of the European Society of Cardiology (ESC), is held 15 to 17 October at the Centro de Congressos de Lisboa in Lisbon, Portugal. The full scientific programme is available here. This year features state-of-the-art presentations by leading experts on “managing risk in acute cardiovascular care”, the congress theme.Professor Doron Zahger, Chairperson of the Scientific Programme, said: “All healthcare professionals working in acute cardiac care manage high risk patients in various situations such as acute heart failure, cardiac arrest, acute coronary syndromes, and high risk arrhythmias which can lead to sudden death.”Acute cardiovascular care is the specialty of cardiology dealing with acute problems in need of urgent care including heart attack, cardiac arrest, and acute heart failure, but also other conditions leading to acute cardiovascular problems such as pulmonary embolism or stroke.Original scientific research will be unveiled in a rich abstract programme covering the entire spectrum of acute cardiac care.
New studies will be presented on the hot topic of diagnosing myocardial infarction in the ambulance and emergency room. Professor Zahger said: “Prompt and accurate diagnosis is essential to ensure that patients receive the right treatment quickly, that the damage caused by heart attack is limited, and that the risk of heart failure is minimised. Accordingly, much research is ongoing in an effort to diagnose myocardial infarction earlier and more accurately.”Novel methods using shock wave therapy or medication for regenerating heart tissue that has suffered from restricted blood supply (ischaemia) will be revealed. The techniques may reduce infarct size, control inflammation, and improve heart function in patients with ischaemic heart disease.Inequalities in treatment of cancer patients who have a heart attack will be presented for the first time. The media will hear first-hand how care of these patients compares to those without cancer and the impact on in-hospital outcomes.
The use of an implantable cardioverter defibrillator (ICD) to prevent sudden death is explored in patients who had an out-of-hospital cardiac arrest that was caused by acute myocardial infarction. “This is a unique use for ICDs and journalists will hear whether or not it shows promise for the future,” said Professor Zahger.ESC Gold Medallist Professor Keith Fox will give a keynote lecture during the inaugural session entitled “Vulnerable plaques in vulnerable patients”, providing journalists with new insights in this exciting field.An innovative virtual case area will showcase interactive demonstrations on a digital patient simulator. Cases with symptoms including palpitations, breathing difficulties, and swollen legs will be enacted in virtual patients created for the congress and discussed by international experts.This is the prime scientific event for all healthcare professionals working in acute cardiac care. More than 1000 delegates from around 80 countries are expected, including cardiologists, emergency physicians, intensive care physicians, interventionists, anaesthesiologists, imaging specialists, internists, cardiac surgeons, nurses, paramedics and other allied professionals who care for acutely ill cardiac patients. With hundreds of abstracts and more than 50 scientific sessions over three days, this is the event of the year in acute cardiovascular care.

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Cardiovascular Disease in the Elderly

Posted by fidest press agency su lunedì, 29 agosto 2016

cardiology congress-2016Rome, Italy Monitoring platelet function in order to individualize antiplatelet therapy did not improve outcomes for elderly patients after a heart attack compared to a standard, unmonitored approach, results of the ANTARCTIC trial show.The findings, presented in a Hot Line session at ESC Congress 2016, and with simultaneous publication in Lancet, challenge current international guidelines which recommend platelet function testing in high risk patients.“Platelet function testing is still being used in many centres to measure the effect of antiplatelet drugs and adjust the choice of these drugs and their doses. Our study does not support this practice and these recommendations,” said senior investigator Gilles Montalescot M.D, Ph.D, from Hôpital Pitié-Salpêtrière, in Paris, France.“Although measuring the effect of antiplatelet agents makes sense in order to choose the best drugs or doses, this costly and more complex strategy does not appear to benefit patients, even when they present with extremely high risk of ischemic and bleeding events liked those enrolled in ANTARCTIC.”
ANTARCTIC is the only study of platelet function testing in elderly patients at very high risk of ischemic and bleeding complications.It enrolled 877 patients, aged 75 years or more, who presented with an acute coronary syndrome and underwent coronary stenting.All patients were started on the antiplatelet agent prasugrel (5mg), with 442 randomised to the conventional therapy (no adjustment) and 435 to monitoring and treatment adjustment, if needed.Patients in the monitoring arm received 14 days of the daily 5mg prasugrel dose, but then underwent a platelet function test at Day 14, followed by medication adjustment, if the test showed high or low platelet reactivity. Additional monitoring was performed at Day 28 in patients who needed treatment adjustment.
The primary end point of the trial was the composite of cardiovascular death, myocardial infarction, stroke, stent thrombosis, urgent revascularization and bleeding complication at 1-year.This endpoint occurred at a similar rate in both arms of the study: 27.6% in the monitoring group, and 27.8% in the conventional group (hazard ratio [HR], 1.003; 95% confidence interval [CI], 0.78 to 1.29; P=0.98).There was similarly no significant difference in rates of the main secondary end point (a composite of cardiovascular death, myocardial infarction, stent thrombosis or urgent revascularization), which occurred in 9.9% and 9.3%, respectively (HR, 1.06; 95% CI, 0.69 to 1.62; P=0.80).“Platelet function monitoring led to a change of treatment in 44.8% of patients who were identified as being over- or under-treated, yet this strategy did not improve ischemic or safety outcomes,” noted Professor Montalescot.
“ANTARCTIC confirms the ARCTIC study (NEJM 2011) in a different population with a different drug, and has addressed the potential limitations of the ARCTIC study, but finally reached the same conclusion. I expect there will be adjustments of guidelines and practice in light of this.”ANTARCTIC stands for Assessment of a Normal versus Tailored dose of prasugrel after stenting in patients
Aged > 75 years to Reduce the Composite of bleeding, stent Thrombosis and Ischemic Complications).

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Moderate physical activity linked with 50% reduction in cardiovascular death in over-65s

Posted by fidest press agency su sabato, 27 agosto 2016

cardiology congress-2016Rome, Italy – 27 Aug 2016 Fiera di Roma (Ingresso Nord, Via Portuense 1645/1647): Moderate physical activity is associated with a greater than 50% reduction in cardiovascular death in over-65s, according to research presented at ESC Congress 2016 today.1 The 12 year study in nearly 2500 adults aged 65 to 74 years found that moderate physical activity reduced the risk of an acute cardiovascular event by more than 30%. High levels of physical activity led to greater risk reductions.“The role of physical activity in preventing cardiovascular disease (CVD) in people of working age is well established,” said Professor Riitta Antikainen, professor of geriatrics at the University of Oulu, Finland. “But relatively little is known about the effect of regular physical activity on CVD risk in older people.”The present study assessed the association between leisure time physical activity and CVD risk and mortality in 2456 men and women aged 65 to 74 years who were enrolled into the National FINRISK Study between 1997 and 2007.Baseline data collection included self-administered questionnaires on physical activity and other health related behaviour, clinical measurements (blood pressure, weight and height), and laboratory measurements including serum nuova-fiera-di-romacholesterol. Participants were followed up until the end of 2013. Deaths were recorded from the National Causes of Death Register and incident CVD events (coronary heart disease and stroke) were collected from the National Hospital Discharge register.The researchers classified self-reported physical activity as:
• Low: reading, watching TV or working in the household without much physical activity.
• Moderate: walking, cycling or practising other forms of light exercise (fishing, gardening, hunting) at least four hours per week.
• High: recreational sports (for example running, jogging, skiing, gymnastics, swimming, ball games or heavy gardening) or intense training or sports competitions at least three hours a week.
During a median follow-up of 11.8 years, 197 participants died from CVD and 416 had a first CVD event.

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“Breaking the Cardiovascular Continuum through Understanding, Recognition, Treatment and Prevention of the Disease”

Posted by fidest press agency su martedì, 24 maggio 2016

vilniusVilnius, Lituania dal 26 al 28 maggio la Fondazione Internazionale Menarini esporta la propria esperienza nell’organizzazione di congressi di medicina di alto livello. Recentemente ha promosso il congresso che si è tenuto a Londra, in collaborazione con il St. George Hospital, polo di ricerca della città inglese. Oggi è la volta del Congresso Internazionale dal titolo “Breaking the Cardiovascular Continuum through Understanding, Recognition, Treatment and Prevention of the Disease”, organizzato dall’Università di Scienze della Salute Lituana, Dalla Facoltà di Medicina dell’Università di Vilnius, dalla Società Lituana di Cardiologia e dalla Società Lituana di Ipertensione. Tra i relatori riconosciuti a livello internazionale per prestigio e competenza in campo cardiovascolare, di cui molti sono italiani, si segnala la presenza di Luis Ignarro, ricercatore di Los Angeles e Premio Nobel per la Medicina, che aprirà il Congresso con una lettura plenaria.

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Rene malato “spia” di problemi di cuore e circolazione

Posted by fidest press agency su giovedì, 12 maggio 2016

trapianto_reneA Genova dal 19 al 21 maggio 2016 ricercatori italiani ed europei tra i più prestigiosi si confronteranno e tracceranno un quadro della situazione della ricerca clinica e di base in ipertensione arteriosa e diabete mellito, due patologie croniche tra le più diffuse nei paesi occidentali: in Italia colpiscono rispettivamente il 30% e tra il 6 e l’8% della popolazione.
Medici e ricercatori ne discuteranno in occasione del Congresso “The kidney, hypertension and cardiovascular risk” organizzato dall’Università degli Studi di Genova e promosso dalla Fondazione Internazionale Menarini.
Ipertensione e diabete costituiscono i principali fattori di rischio per lo sviluppo e la progressione della malattia renale croniche, anch’essa in drammatico aumento negli ultimi anni. La malattia renale cronica, spesso del tutto asintomatica, colpisce attualmente circa il 10% della popolazione e comporta un notevole aumento del rischio di incidenti cerebro e cardiovascolari, rappresentando, direttamente o indirettamente, un importante fonte di spesa per i sistemi socio sanitari dei paesi industrializzati.
Nel corso del convegno verranno presentati i risultati degli studi condotti dai ricercatori del Centro Ipertensione dell’Azienda Ospedaliera Universitaria San Martino di Genova, in corso di pubblicazione su prestigiose riviste internazionali, che dimostrano come l’identificazione di alterazioni renali anche lievi ed asintomatiche consentano di individuare facilmente ed a basso costo i pazienti con ipertensione a più elevato rischio di sviluppare complicanze.
Queste nuove acquisizioni possono avere importanti ricadute nella pratica clinica poiché semplificano la valutazione del rischio cardiovascolare dei pazienti a rischio come i diabetici e/o gli ipertesi.
Il congresso di svolge dal 19 al 21 maggio 2016 a Palazzo Ducale, Piazza Giacomo Matteotti 9. La partecipazione è aperta ai medici e assegna crediti formativi ECM.

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Record attendance expected at Europe’s leading cardiovascular magnetic resonance meeting

Posted by fidest press agency su mercoledì, 13 aprile 2016

scompenso cardiacoSophia Antipolis. Record attendance is expected at Europe’s leading cardiovascular magnetic resonance meeting, to be held 12 to 14 May in Florence, Italy, at the Palazzo dei Congressi.EuroCMR is the largest and most important cardiovascular magnetic resonance, or CMR, event in Europe. It is the annual CMR conference of the European Association of Cardiovascular Imaging (EACVI), a registered branch of the European Society of Cardiology (ESC). The scientific programme is available here. More than 500 delegates are anticipated to attend and a record number of abstracts have been submitted for presentation. Professor Sven Plein, chair of the EACVI’s CMR Section, said: “The use of CMR as a safe, accurate and very versatile diagnostic tool continues to expand rapidly. This is now the largest clinical CMR meeting in Europe and is becoming an increasingly popular place to present new science and hear the latest developments in the field. This is the event for journalists to get up-to-date on CMR.” The hot topic of parametric mapping by CMR will be covered by multiple abstracts and a number of talks including pro and contra sessions on whether it is ready for clinical use. Parametric mapping provides quantitative parameters for different diseased and non-diseased cardiac tissues. It also allows visualisation of subtle changes in the myocardium such as fibrosis.“Mapping heralds a new era in CMR,” said Professor Holger Thiele, programme chair of EuroCMR. “It is comparable to the Hounsfield units in computed tomography (CT) imaging and is an important step forward for quantification in CMR.”The world famous pathologist Dr Christina Basso will show anatomical specimens and CMR images of cardiac pathologies for the first time during EuroCMR. A special course on fluidodynamic modeling will be led by Dr Philip Kilner demonstrating fluid and flow experiments and the implications for CMR. Professor Albert van Rossum will give the key note lecture on the role of CMR in the two-edged sword of reperfusion in myocardial infarction.Cutting edge science will be revealed in the original scientific abstracts. A rapid fire abstract session has been introduced this year which will see the best science presented orally within a few minutes.
EuroCMR covers the full spectrum of the clinical application of CMR from congenital heart disease to all adult cardiac diseases. This is reflected in the congress theme “current clinical application of CMR”. A session on advanced technologies in congenital heart disease will explore when to use real-time imaging and how 3D printing can help diagnosis and management planning. Another session is devoted to the use of CMR to plan and guide procedures such as cardiac device implantation and ablation of atrial fibrillation.
Professor Thiele said: “Leaders in the field will discuss state of the art clinical applications of CMR and release cutting edge findings from scientific research.” Controversial issues in CMR will be tackled head on and members of the press will get both sides of the story. A symposium on the use of contrast agents in CMR will ask whether CMR causes DNA damage. The role of CMR in evaluating the cardiovascular effects of recreational drugs will also be debated. Professor Plein said: “Experts will separate myth from fact and tell members of the press what is known on several contentious issues.” A new face-off session will be held in which post-processing software companies battle to show the performance of their software for quantification. Delegates’ knowledge will be tested in the CMR World Cup Competition in which expert teams, symbolically representing England and Germany 50 years after the famous world cup final between the two nations, will be asked difficult and trivia questions related to CMR in a highly entertaining showdown.Professor Thiele said: “EuroCMR is the top CMR event in Europe. Journalists should register now to discover the clinical and scientific advances in this fast moving field. More than 90 international speakers will tell us what is new during 2.5 days and over 40 sessions.”
The European Society of Cardiology (ESC) represents more than 95 000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe.

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Cardiovascular prevention in refugees on nursing conference agenda

Posted by fidest press agency su lunedì, 21 marzo 2016

ateneSophia Antipolis. In line with current events and particularly pertinent to Greece, cardiovascular prevention in refugees and other marginalised groups is on the agenda of EuroHeartCare 2016, which will be held 15 to 16 April at the Megaron Athens International Conference Centre in Athens, Greece.
EuroHeartCare is the official annual meeting of the Council on Cardiovascular Nursing and Allied Professions (CCNAP) of the European Society of Cardiology (ESC). This year’s meeting is held in collaboration with the Hellenic Society of Cardiovascular Nursing.
Experts will discuss the challenges and practicalities of providing preventive cardiac care in marginalised groups including refugees and Roma. “The humanitarian crisis in the Middle East highlights the difficult conditions refugees live in,” said Dr Jeroen Hendriks, CCNAP communications officer. “Journalists will hear whether cardiovascular prevention is feasible in different cultures and situations.”Delegates from around 40 countries are set to attend the two day scientific congress. The packed programme includes 13 scientific sessions with lectures from leaders in the field. Original research will be presented in more than 200 abstracts, providing stories for the press. The scientific programme is available here.Cutting edge cardiovascular prevention and risk reduction is the focus of a session that will report the latest news on the link between periodontal disease (also called gum disease) and cardiovascular disease. Dr Hendriks said: “Smoking, lack of physical activity, diabetes and high blood pressure are well known risk factors for heart disease. Novel targets for reducing risk will be explored in this session.”This year’s theme is “Excellence in patient care: the heart of EuroHeartCare”. Innovative approaches to cardiovascular care will be highlighted, for example challenges in implementing psychosocial interventions, palliative care in cardiovascular disease, and nurse-led management of arrhythmias. Dr Hendriks said: “Excellence in patient care requires actively involving patients and providing patient education, and nurses have a crucial role in achieving that.”
Results of a CCNAP survey based on the launch of the Guidelines Toolkit in 2015 will be presented for the first time in full and reveal what prevents nurses from implementing clinical practice guidelines. “Nurses face a number of barriers to putting guidelines into practice,” said Dr Gabrielle McKee, programme chair of EuroHeartCare. “Whilst in some countries it is perfectly acceptable for nurses to prompt a physician to prescribe a medication that has been forgotten, for example an anticoagulant for a patient at high risk of stroke, in other countries nurses feel obliged to simply follow doctors’ orders without question.” Also on the topic of guidelines, a session on the latest in arrhythmia management will underline the implications for nurses of the 2015 ESC guidelines on the prevention on ventricular arrhythmias and sudden cardiac death.Advances in cardiac care have improved prognosis, especially for patients with heart failure. This has led to an emerging need for high quality palliative care. “Delegates and the media will discover the most up to date knowledge and practice in this developing field,” said Dr Hendriks. Dr McKee said: “EuroHeartCare is the event of the year for cardiovascular nurses and allied professionals. Journalists should mark their calendars to get up to the minute evidence on hot topics in this exciting field.”

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