Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 33 n° 244

Posts Tagged ‘devlopment’

Development of novel therapeutics to address global unmet medical needs

Posted by fidest press agency su giovedì, 12 settembre 2019

Aptorum Group Limited (Nasdaq: APM) (“Aptorum Group”), a biopharmaceutical company announces that it has initiated investigational new drug (IND)-enabling studies for ALS-4, a small drug molecule candidate indicated for the treatment of infections caused by Staphylococcus aureus (or “S. aureus”) including methicillin-resistant Staphylococcus aureus (MRSA, i.e., one of the commonly known “super-bugs”) based on a novel anti-virulence approach.The ALS-4 candidate has been progressing well and the first series of GLP toxicology studies have been completed through an appointed North American based contract research organization (CRO). In particular, ALS-4 candidate did not show any mutagenicity in the in vitro Ames tests. ALS-4 development is on track and the company targets to submit the related IND in the first half year of 2020 and a hybrid Phase 1 clinical study is currently planned in North America with both healthy volunteers and patients to obtain preliminary efficacy readout.
S. aureus is a bacteria which is a leading cause of blood, lung, skin, bone and device-related infections, as well as toxin-related diseases1. It is estimated that patients with S. aureus bacteremia have an average mortality rate of 30%2 and that it is responsible for causing more deaths than AIDS, tuberculosis and viral hepatitis combined3. MRSA and vancomycin-intermediate and resistant S. aureus have also been classified by the World Health Organization (WHO) as high priority pathogens for research and development

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Modern Commercial Navy

Posted by fidest press agency su giovedì, 9 luglio 2009

Modern Commercial Navy (MCN) PLC and United Industrial Corporation JSC have signed a cooperation agreement, anticipating the developmental work of technical and commercial operation factors of the construction of multifunctional supply icebreaker and also tankers for transportation of liquefied natural gas. The tankers’ capacity total 75 000 m³.  A signing ceremony was held within the frameworks of the XIII St. Petersburg International Economic Forum. Referring to this document MCN PLC is the largest Russian shipping company with longstanding experience of collaboration with shipbuilding enterprises. The company is the largest customers of Russian civil shipbuilding and is interested in placing orders for the construction of high-technological maritime civil vessels at OPK’s shipyards. OPK’s shipbuilding assets, including Severnaya Verf PLC and Baltiysky Zavod PLC, rank among the leading Russian enterprises, specializing in the construction of maritime civil vessels. According to the agreement, OPK’s shipyards are intended realizing its production potentialities to compete in the world market and to realize and develop commercial shipbuilding. This bilateral agreement will contribute to the realization of the Federal Target Program 2008-2015 “Development of Russian Shipbuilding industry”. The program targets civil navy renovation and continental shelf development.

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