Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 33 n° 18

Posts Tagged ‘embryology’

Merck destina 1,5 milioni di Euro al Grant for Fertility Innovation (GFI) per il periodo 2016/17

Posted by fidest press agency su venerdì, 8 luglio 2016

merckDarmstadt, Germania. Merck, azienda leader in ambito scientifico e tecnologico, ha annunciato oggi che continuerà a sostenere il progresso scientifico nel campo della fertilità attraverso il Grant for Fertility Innovation (GFI).
Nel periodo 2016/17 a questo programma saranno destinati finanziamenti per un totale di 1,5 milioni di Euro. L’annuncio è stato dato nel corso del 32° congresso annuale della European Society of Human Reproduction and Embryology (ESHRE) che si sta svolgendo a Helsinki, Finlandia.Il GFI, lanciato nel 2009 all’ESHRE, è dedicato a trasformare i più innovativi progetti di ricerca traslazionale nel campo della fertilità in soluzioni concrete che migliorino i risultati delle tecniche di procreazione medicalmente assistita (PMA). Quest’anno, sono stati selezionati 6 progetti vincitori tra le 112 candidature provenienti da tutto il mondo con l’obiettivo comune di aumentare le possibilità per le coppie di concepire un bambino. il finanziamento ad ogni progetto sarà suddiviso in tre tranches, che saranno assegnate al raggiungimento di specifiche fasi della ricerca.
“Il Grant for Fertility Innovation testimonia il nostro straordinario impegno a migliorare i risultati nei pazienti che hanno bisogno di nuove soluzioni per la fertilità” ha affermato il Dottor Steven Hildemann, Global Chief Medical Officer and Head of Global Medical e Safety di Merck. “Il GFI ha già permesso ai ricercatori più meritevoli di accelerare scoperte scientifiche e ricerca traslazionale per la cura della fertilità, utilizzando un’ampia rete globale di competenze, frutto della collaborazione tra il mondo accademico e l’Azienda”.Questi i premiati del GFI, annunciati nel corso della cerimonia che si è svolta il 5 luglio in occasione del Congresso ESHRE.
– Stephen Andrew Krawetz, Ph. D. – Wayne State University School of Medicine, Detroit, USA – Progetto: “A Retrospective Controlled Cohort Study of Sperm RNAs Guiding the 2 Treatment of the Idiopathic Infertile couple”
– Lynne O’Shea, B.Sc. (Hons.), Ph. D. – UCD School of Medicine and Medical Science, University College Dublino, Irlanda – Progeto: “Using a biomarker of oocyte quality to improve embryo selection during assisted 1 reproduction”
– Paola Piomboni, Ph. D., Ricercatore – Università di Siena, Italia – Progetto: “Exosomal Profile of the Receptive Endometrium: A source of non-invasive biomarkers for Guiding of a Successful Embryo Implantation”
– Qingling Yang , Ph. D.– Reproductive Medical Center of the first Affiliated Hospital of Zhengzhou University, Cina – Progetto: “Telomere length test of cell free genomic DNA in spent embryo medium as a non-invasive biomarker for assessing embryo developmental potential”
– Professor Ernest Hung Yu Ng, Professor William Shu -biu Yeung – University of Hong Kong, Cina – Progetto: “Human embryonic stem cell-derived trophoblastic spheroids (BAP-EB) as a predictive tool for endometrial receptivity and pregnancy rate of in vitro fertilization treatment”
– Professor Fulvio Zullo – Università Magna Graecia di Catanzaro, Italia – Progetto: “Periostin a new non-invasive parameter for evaluating oocyte/blastocyst quality and its impact on endometrial receptivity”

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Early embryos and genetic abnormalities during devel

Posted by fidest press agency su mercoledì, 6 luglio 2011

Stockholm, Sweden: Researchers have found the first direct evidence that early embryos with genetic abnormalities can correct their faults as they develop, marginalising cells with an incorrect number of chromosomes, while allowing the growth of normal cells. Professor William G. Kearns told the annual meeting of the European Society of Human Reproduction and Embryology that a three-day-old embryo (called a cleavage stage embryo) with an incorrect number of chromosomes (known as “aneuploidy”) was capable of undergoing “a dynamic process of genetic normalisation” so that by day five, when it had developed to the blastocyst stage, it had become euploid, with the correct number of chromosomes. The findings have significant implications not just for preimplantation genetic screening (PGS) during fertility treatment, but also for future, cell-based, stem cell treatments for conditions ranging from haematological disorders to neurological damage.
In a statement before the conference, Dr Brezina explained: “In the IVF laboratory, all embryos that undergo PGS on day three are cultured to the blastocyst stage of development at day five, at which time the PGS results are available. In this study we evaluated all embryos that developed to the blastocyst stage with documented chromosomal abnormalities not compatible with a live birth from a cell taken from the embryo on day three. At the blastocyst stage, the embryo has developed into two parts; the inner cell mass (ICM), which has cells that will form the foetus, and the trophectoderm (TE), which has cells that will form the placenta. Instead of taking a biopsy from either of these cell types, we dissected the entire embryo and captured as much of the ICM and TE cells as possible. These ICM and TE cells were isolated into two separate groups. Using microarrays we tested these groups for chromosomal abnormalities. We had the potential to detect mosaicism (the presence of several different cell lines within a single embryo) at a rate of approximately five percent, but we did not see mosaicism in any of the ICM or TE samples evaluated.
Out of the 126 embryos, 62 (49.2%) were euploid and 64 (50.8%) were aneuploid at day three; of these 43 (69.4%) of the euploid embryos developed to the blastocyst stage, while only 25 (39.1%) of the aneuploid embryos did. Of the 25 aneuploid day-five embryos, 68% possessed a euploid ICM and 76% possessed a euploid TE, with 64% having both a euploid ICM and TE. Therefore, 16 of the 25 had correction in both the TE and ICM cells.
For fertility treatment, the discovery that a large percentage of embryos deemed to be abnormal at day three could become normal at day five suggests that during PGS, day five is the better time to predict the ultimate chromosomal status of the embryo, rather than day three. In addition, if a day-three embryo was found to be aneuploid, then these findings suggest that it would be worth waiting and testing the trophectoderm at day five before making the final decision about whether to implant the embryo or discard it. Determining the mechanisms that govern the process of genetic normalisation in the developing human embryo is the next stage of research for Dr Brezina and Prof Kearns and their colleagues. Abstract no: O-133 Tuesday 10.00 hrs CEST (Rooms K1 + K2)

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Meeting Society of Human Reproduction and Embryology

Posted by fidest press agency su lunedì, 10 gennaio 2011

The European Society of Human Reproduction and Embryology (ESHRE) announced today that it has chosen Istanbul for its 2012 Annual Meeting. During 1 to 4 July 2012, ESHRE will hold its Annual Meeting at the Istanbul Congress Centre (ICC).  Reproductive medicine is one of today’s most exciting scientific and clinical areas. Every month there are announcements of medical ‘firsts’, new rulings by regulatory bodies or ethical controversies. These often spark a heated debate among practitioners in the field, ethicists, legislators, the media and the public.ESHRE’s Annual Meeting is the forum where more than 9,000 of the world’s leading experts in reproductive medicine gather to give a public presentation of their latest research findings.  During the four day meeting, issues that present policy-makers and ethicists with some of the most challenging problems and difficult decisions will be discussed. “We are particularly delighted that ESHRE, for the first time, holds its meeting in Istanbul. Located on two continents ESHRE’s Annual Meeting in Istanbul will bridge the border between East and West, hopefully attracting more participants from the Middle and Far East, India and Russia,” says Dr. Anna Veiga, chairman elect, who will preside over the meeting as future chairman. Istanbul in the summer is a charming and exhilarating venue. It is endowed with unrivalled beauty and complimented by a unique juxtaposition of ancient and modern times. The excellent scientific programme, the colorful social activities coupled with the breathtaking panorama and exotic surroundings of Istanbul will make this Annual Meeting a rewarding educational, social and cultural experience.

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Pre-implantation genetic screening

Posted by fidest press agency su venerdì, 22 ottobre 2010

The European Society of Human Reproduction and Embryology (ESHRE) has published a set of guidelines for best practice Preimplantation Genetic Diagnosis (PGD)/Screening (PGS) to give information and guidance to potential and existing PGD centres. The four guidelines include one outlining the organisation of a PGD centre and three relating to the methods used: amplification-based testing, fluorescence in situ hybridisation (FISH)-based testing and polar body/embryo biopsy.
The first guideline on the organisation of a PGD centre includes the basic requirements of an IVF/PGD centre, transport PGD (when the gametes and embryos to be tested are in a different centre than the patient), inclusion/exclusion criteria for patients, staffing, genetic counseling and accreditation of a centre. The three more technical guidelines additionally cover laboratory requirements, clinical protocols and follow-up recommendations after diagnosis for each of the PGD methodologies: amplification-based testing, FISH-based testing and polar body/embryo biopsy. The guidelines on amplification-based and FISH-based testing also outline quality control and quality assurance and the diagnostic confirmation of untransferred embryos. Freezing of embryos after biopsy is covered in the fourth guideline on the use of embryo biopsy in PGD/PGS.
Pre-implantation genetic screening (PGS) has been included in all guidelines. Although current evidence suggests it may be ineffective at the embryo cleavage stage using current technology, PGS may still show improved delivery rates if used at the blastocyst stage or on polar bodies. The ESHRE group decided deliberately to include PGS recommendations to assist every professional in the reproductive field to develop the best laboratory and clinical practice possible.

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Robert Edwards honoured as Nobel laureate

Posted by fidest press agency su martedì, 5 ottobre 2010

Brussels. ESHRE, the European Society of Human Reproduction and Embryology, warmly and proudly welcomes today’s announcement that the Cambridge reproductive biologist Robert Edwards has been awarded the Nobel Prize for Medicine. Bob was a founder member of ESHRE and became the Society’s first chairman in 1985. The following year, under his drive and direction, ESHRE published the first issue of its journal, Human Reproduction, with Bob as editor, a role he was to continue for the next 15 years. Working with the gynaecologist Patrick Steptoe, Bob had pioneered the birth of the world’s first IVF baby, Louise Brown, who was born in Oldham, UK, on 25th July 1978. Her birth – as well as Bob’s own enthusiasm and personal guidance – proved an inspiration to many other groups around the world to establish their own IVF programmes. Dr. Luca Gianaroli, ESHRE’s current chairman, says: “Without Bob there would be no ESHRE and no Human Reproduction, and all of us working in reproductive medicine would be the poorer for that. There can be few embryologists or IVF specialists today whose career and expertise have not been shaped in some way by ESHRE’s training and journals – and this is something we all owe ultimately to Bob. Today, ESHRE is the only group in the world to systematically collect IVF data on a cycle-by-cycle basis. The latest estimates, when added to other reports, put current global IVF activity at 1.5 million cycles per year. This corresponds to around 300,000 babies born each year, and a cumulative total of 4.3 million since Louise Brown in 1978. Average delivery rate treatment (in 2006) was 22.1%,

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Human Reproduction & Embryology

Posted by fidest press agency su venerdì, 18 giugno 2010

Rome Sunday 27 June – Wednesday 30 June 2010 Fiera Via Portuense, 1645-1647 26th Annual Meeting
Monday 28 June (11:45 – in English) Chair: Dr. Luca Gianaroli, ESHRE Chairman • Drs. Srilatha Gorthi and Julie Nekkebroeck: Two studies of women’s attitudes to ‘social egg freezing’ find that   younger and older women have different reasons for delaying motherhood • Dr. Kelechi Nnoaham: Endometriosis has a significant effect on women’s work productivity, first worldwide study finds  Dr. Vivian Rittenberg: Are overweight women undertaking ART more likely to miscarry?
Monday 28 June (13:00 – in Italian) Chair: Dr. Luca Gianaroli, ESHRE Chairman  Dr. Anna Pia Ferraretti: Italian patients amongst the most mobile in crossing borders for ART
• Dr. Paolo Emmanuele Levi Setti: Italian Constitutional Court modifications of a restrictive ART law improve pregnancy rates • Mrs. Filomena Gallo (patient association Amica Cicogna): Italian judges move to protect couples’ rights
Tuesday 29 June (10:00 – in English) Chair: Dr. Anna Veiga, ESHRE Chairman elect • Dr. Maria Lalioti: Researchers discover why some women are sub-fertile and have a poor response to ovarian stimulating hormones • Dr. Suzanna Frints: A cheap and simple, non-invasive blood test could replace invasive diagnostic techniques in early pregnancy • Dr. Cecilia Høst Ramlau-Hansen: Does drinking alcohol during pregnancy affect sperm quality in sons?
Wednesday 30 June (09:15 – in English) Chair: Professor Joep Geraedts, ESHRE past chairman • Dr. Ana Cristina Cobo Cabal: Are on-going pregnancy rates from vitrified eggs as good as those from fresh? New randomised trial has the answer • Dr. Alicia Armstrong: New non-surgical treatment for uterine fibroids can improve quality of life and maintain fertility • Dr. Jacques de Mouzon and Dr. Karl Nygren: Data from the ESHRE European IVF Monitoring Group and world data from the International Committee for Monitoring Assisted Reproductive Technologies (ICMART)

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Nuovo presidente dell’Eshre

Posted by fidest press agency su mercoledì, 1 luglio 2009

L’Italia alla guida della medicina della riproduzione europea. Luca Gianaroli, consulente del comitato scientifico di SISMER (Società Italiana di Studi di Medicina della Riproduzione) di Bologna, è stato eletto presidente dell’ESHRE -European Society of Human Reproduction and Embryology- durante il congresso annuale dell’associazione in corso ad Amsterdam (Olanda). Secondo italiano a ricoprire l’importante carica nei 25 anni di vita dell’ESHRE, Gianaroli è però il primo presidente in assoluto che opera esclusivamente in una struttura privata: tutti i suoi predecessori arrivavano da esperienze nel pubblico.  «Sono onorato di poter ricoprire questa importante carica soprattutto per il ruolo autorevole che ESHRE si è guadagnata nella sua storia nell’ambito della medicina della riproduzione -commenta Gianaroli-. Sarà mia cura lavorare affinché le conquiste ottenute con la sentenza della Corte Costituzionale possano rappresentare un passo concreto per allineare l’Italia all’Europa».
ESHRE, fondata a Bonn (Germania) nel 1984 in occasione del suo primo congresso, rappresenta l’associazione più grande del mondo nel campo della medicina della riproduzione. In 25 anni, gli iscritti sono passati da 349 a oltre 4.200, tra medici, ricercatori, studenti e personale di supporto alle attività di scienza e medicina della riproduzione, provenienti da 114 Paesi differenti. Gianaroli succede all’olandese Joep P.M. Geraedts, in carica dal 2007.
Luca Gianaroli, profilo professionale – Anno di nascita: 1953. Laurea: Medicina e Chirurgia (1978). Corsi di specializzazione: Ostetricia e Ginecologia (1982). Attività scientifica: dal 1975 al 1984, vincitore di concorsi e borse di studio per soggiorni esteri presso rinomati centriDal settembre 2005 al gennaio 2006 presidente della Società Internazionale di Diagnosi Genetica Preimpianto (PGDIS). Dal gennaio 2006 presidente della Società Italiana della Riproduzione (S.I.d.R.). Dal 2000 al 2003: Editore Associato per Human Reproduction; dal 2004 ad oggi: Membro dell’Editorial Board di Reproductive Biomedicine Online.
Sismer – Società Italiana di Studi di Medicina della Riproduzione – Opera nell’ambito dell’infertilità umana e della procreazione medicalmente assistita dal 1994. SISMER costituita come realtà indipendente, lavora con medici, biologi e personale infermieristico specializzato, svolge attività scientifica e di ricerca. È in grado di far fronte a qualsiasi necessità della coppia infertile. La sede centrale è a Bologna (via Mazzini, 12) con centri satellite dislocati in altre regioni italiane.

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