Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 32 n° 302

Posts Tagged ‘model’

Scientists at Children’s Hospital Los Angeles Develop Breakthrough In Vitro Model

Posted by fidest press agency su venerdì, 16 agosto 2019

Kidneys work to constantly filter blood and remove toxins from the body. Conditions such as chronic kidney disease (CKD) are characterized by a reduced ability to perform this essential function. CKD incidence is growing and more than 1.4 million individuals depend on dialysis or kidney transplant for survival. Development of new treatments requires an understanding of the mechanisms of the disease progression, but scientists have not been able to accurately model kidney filtration in vitro – until now.
In a landmark study published in Nature Communications, scientists at Children’s Hospital Los Angeles demonstrate an in vitro kidney model that could change the course of research for diseases like CKD.The kidney contains specialized structures called glomeruli. Within each glomerulus is a filtration barrier made up of two thin layers of highly specialized cells and a membrane that acts as a selective filter. As blood moves through each glomerulus, toxins and small molecules can pass through, while proteins and other important components are kept in the bloodstream. “This filtration process breaks down in patients with kidney disorders,” explains Laura Perin, PhD, who is co-senior author on the study along with Stefano Da Sacco, PhD. “But because we haven’t had a good in vitro model, we still don’t know the mechanisms of injury to the glomerulus in CKD.” Dr. Perin and Dr. Da Sacco conduct research in the GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology along with co-director Roger De Filippo, MD, at CHLA’s Saban Research Institute. The lead author on the study was CHLA postdoctoral research fellow Astgik Petrosyan. Together, the team studies the structure of the glomerulus to better understand how and why their ability to filter blood breaks down.

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Parexel Launches Enhanced Integrated Functional Service Provider Model

Posted by fidest press agency su martedì, 25 giugno 2019

Parexel, a leading provider of solutions to accelerate the development and delivery of innovative new therapies to market to improve world health, from Clinical through to Commercialization, today launched an enhanced integrated outsourcing delivery model for Functional Service Provider (FSP) services at the DIA 2019 Global Annual Meeting in San Diego. Parexel FSP reflects the company’s strategic focus on offering patient-focused customer solutions tailored to the changing needs of its biopharma customers, from full service to functional to a hybrid approach. Customers have access to multifunctional expertise and resources through a single point-of-contact while maintaining business continuity and productivity to drive efficiency, reduce complexity and accelerate time to market.“With functional services and related blended models representing a significant proportion of total clinical development spend today, biopharma companies need flexible and hybrid approaches to their outsourcing needs,” says Peyton Howell, Executive Vice President and Chief Commercial & Strategy Officer. “Parexel is an FSP ideal partner, with a proven track record in connecting and delivering targeted needs with increased expertise across functional services and an ability to integrate seamlessly with our customers’ teams.”Parexel is a pioneer in the development and delivery of a wide range of FSP, full service and flexible clinical development services, with more than 1,400 projects delivered. “Parexel is able to further leverage our ExecuPharm and TMAC (The Medical Affairs Company) subsidiaries — well-respected companies providing functional outsourcing in the biopharma space — with our broader FSP offering to provide a comprehensive FSP and hybrid capability unmatched in our industry,” notes Ms. Howell. “For example, our ExecuPharm subsidiary provides biopharma customers with qualified professionals across functional areas, including clinical monitoring and study management. TMAC provides strategic and tactical solutions, including contract field based medical teams, medical science liaisons, medical information and medical affairs consulting.”

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Stochastic Ising model with fast decreasing temperature

Posted by fidest press agency su lunedì, 17 ottobre 2016

temperaturaRoma Mercoledì 19 Ottobre 2016, ore 14:30 Dipartimento di Matematica e Fisica, Aula 311 Largo San Leonardo Murialdo,1 – In the regime of temperature fast decreasing to zero, results on the stochastic Ising models are presented. A k-dynamics allowing to flip sets of k spins at the same time is also introduced showing that the behavior of the models deeply depends on this parameter. For these models we follow the classification of Gandolfi, Newman, Stein (2000), i.e. a model is of type F if any spin flips finitely many times a.s., it is of type I if any spin flips infinitely many times a.s., or it is of type M otherwise. Conditions to obtain models of type F, I, or M and examples are discussed. Prof. Emilio De Santis, Università La Sapienza.

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Poverty and Inequalities on the RiseJust Social Models needed as the solution

Posted by fidest press agency su martedì, 17 febbraio 2015

povertyA study of the impact of the European crisis and austerity on people, with a special focus on Cyprus, Greece, Ireland, Italy, Portugal, Romania and SpainSpeakers include: Antonio Tajani (European Parliament Vice-president, EPP), David-Maria Sassoli (European Parliament Vice-president, S&D), Lieve Fransen (Director for Social Policies & EU2020 at the EU Commission, Jorge Nuño Mayer (Caritas Europa Secretary General), Walter Nanni (Head of Caritas Italiana Research Unit). Tiziana Ciampolini (Head of Caritas Torino Observatory). Moderator: Susanna Petruni (TG1 RAI Vice-director).In addition, representatives from Caritas Greece, Caritas Italy and Caritas Spain will present the situation in their countries, based on their work on grass-root level with the poor and unemployed.
The report, commissioned by Caritas Europa and Caritas organisations in 7 EU Member States, is the third annual edition in a series of in-depth examination on the impact that current policies are having on people in the EU countries worst affected by the economic crisis. It describes the human impacts of the crisis and of austerity policies, and documents the growing number of people struggling with poverty and inequalities.The Report also informs on measures undertaken by the EU and national authorities and on the impact of the “Troika Programmes”. Furthermore, it shows how the crisis has affected access to social services and healthcare, and deepened the difficult situation of children and their families.The last two editions of the Crisis Monitoring Report were well received and acknowledged by many European stakeholders; institutions, civil society organisations and media. (Photo: poverty)

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Developing Regions of Eastern Europe to Drive EU Aftermarket Growth, Says Frost & Sullivan

Posted by fidest press agency su giovedì, 13 marzo 2014

London, UK While a major distribution group in Francecollects data to support a planned expansion in Poland and neighbouring countries, an established Tier-one supplier of mechanical engine parts in Belgium explores the potential launch of electrical components to customers in southern Europe. A major automaker at the same time commissions a study to analyse pricing and recommended inventory levels for spare parts in the former Russian territories. These are just a few examples taken from Frost & Sullivan research enquiries, that exemplify how in 2013, interest in the European automotive aftermarket was significantly higher than recent years. The European automotive aftermarket is a €100 billion industry for parts suppliers from Ireland to Russia, according to latest research from Frost & Sullivan (, with total revenue increasing by auto corsaapproximately 2.4 percent annually. It has fully recovered from its dip in 2009-2010, when economic recession caused motorists to defer normal vehicle maintenance. Growth for routine maintenance parts such as tires and lighting will outpace the market as a whole. For electronic parts, including position and pressure sensors, year-over-year growth will be as high as ten percent. There is also a growing demand for remanufactured products, as successful cross-border core collection programs pave the way for lower priced starters/alternators and clutch parts, among others.“In Eastern Europe, growth rates are significantly higher,” Spivey continues. “Russia’s vehicles in operation are forecast to increase more than three times faster (3.3 percent) than the rest of Europe. In Poland, new vehicle sales grew 6.4 percent for 2013 – the highest in three years – boosting the automobile population there. Overall, Eastern Europe’s car park will grow by 2.6 percent annually – more than twice as fast as the rest of the continent.” European countries, increasing the likelihood that their owners will pay for the repairs instead of trading in the car.However, product selection and distribution channels also vary significantly from country to country – presenting another potential obstacle to growth in the region. Internet retailers are expected to enjoy the highest growth, with tire companies leading the migration to online sales. Sales through major online marketplaces such as and eBay, as well as more specialised e-retailers Rakuten and Oscaro, will more than quadruple over the next decade – accounting for more than ten percent of industry revenue. On the whole, the European automotive aftermarket has been opening up to outside competition since 2002, when the initial “Block Exemption” regulation allowed vehicle owners to use aftermarket parts and service without voiding their warranty for the first time. Since then, “Right-to-Repair” type legislation requiring automakers to share electronic data, allowing independent repairers to identify part numbers by make and model, has fuelled the growth of “fast-fit” centres, mass merchants and retailers carrying parts that were typically available to vehicle owners only through dealerships.The OES channel has been losing approximately one market share point annually since these regulations took effect.

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European Investment Bank agrees GBP 175m backing to upgrade Scotland’s core motorway network

Posted by fidest press agency su martedì, 25 febbraio 2014

World_BankThe European Investment Bank, Europe’s long-term lending institution, has agreed to provide a funding contribution of GBP 175 million towards the completion of the motorway link between Glasgow and Edinburgh. The investment programme will include both completion of the M8 motorway between Scotland’s two largest cities and major improvements to the M73 and M74. Drivers will benefit from reduced congestion as well as safer and quicker journeys as a result of the new M8 M73 M74 Motorway Improvements Project. The scheme will create hundreds of jobs during construction and, once complete, will significantly reduce congestion on one of Scotland’s busiest road networks. Long-term employment opportunities will also be created throughout the 30 year operation and maintenance of the new roads. Advanced works are currently underway and the road link will be designed, built, operated and maintained for 30 years following award of a concession agreement by the Scottish Government.“The European Investment Bank is committed to supporting crucial investment in essential infrastructure across Europe and we recognise the importance of the M8 scheme to upgrade Scotland’s core motorway links. This project will not only provide economic benefits during construction, but will also improve safety and reduce costs for business in the years ahead through improved travel times. We are committed to providing significant long-term financial support for the scheme.” said Jonathan Taylor, European Investment Bank Vice-President responsible for the UK and Ireland.Transport Minister, Keith Brown, said: “This marks a significant milestone in the timeline of what is a major transport infrastructure project for Scotland. Not only will these works vastly improve connectivity across Scotland’s Central Belt, the project will deliver far reaching benefits to the wider Scottish economy.“We’ll see the creation of hundreds of new jobs which will leave a lasting legacy of a highly-skilled workforce, bolstering Scotland’s construction industry. In addition, the project will act as a catalyst to attract significant inward investment and stimulate continued growth of our business communities.” Debt financing for the project is equally split between a direct loan from the European Investment Bank and a bond placement with international investors. The new Scottish scheme represents the first UK road project involving bond finance since the global financial crisis in 2008, and is the largest project to be financed through the Scottish Government’s Non-Profit Distributing model.The European Investment Bank is committed to supporting crucial investment that stimulates economic growth and improves lives in Scotland. This has included recent support for investment such as the new City of Glasgow College and there is a strong pipeline of future projects currently under consideration by the EIB including new hospitals, transport infrastructure and other flagship investment across Scotland. Over the last five years the European Investment Bank has provided more than GBP 4 billion for transport investment across the UK. Last year represented a record for overall EIB engagement in the UK, GBP 4.85 billion in 2013, up 59% from 2012. The European Investment Bank (EIB) is the long-term lending institution of the European Union owned by its Member States. It makes long-term finance available for sound investment in order to contribute towards EU policy goals.

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Bricks and Clicks sales model gains ground in the automotive industry as dealerships turn to digitization to engage customers

Posted by fidest press agency su martedì, 28 gennaio 2014

london-centralLONDON, U.K. The disruptive influence of connectivity is changing the way business is conducted even in traditional industries such as automotive. High real-estate costs, expensive resources, and need for innovation to stay afloat have compelled many automotive dealerships to shrink store space by about 20 percent and resort to digitization for interactivity with the customer. As bricks and mortar gives way to a bricks and clicks sales model, European OEMs are pushing for standalone digital formats while North America seems to prefer digitisation within existing franchise models.New analysis from Frost & Sullivan (, The Advent of Digital Retailing and its Impact on Car Dealership Structures, finds that global passenger car companies are desperate to innovate and adopt a new retail model to the next generation of young car buyers, the so-called generation Y, a generation that engages through collaborative consumption and targeted digital marketing campaigns. Frost & Sullivan expects that by 2020, 60-70 percent of new car sales leads are likely to be generated by a digital platform, be it websites, mobile sites, social media or apps.Automotive major, Audi, is at the frontline of this change in retail network. Its digital showroom (Audi City), in an upscale shopping zone in London, presents the entire line-up of 40 models virtually. It encourages visitors to configure their dream cars on multi-touch tables, investigating all the possible options by themselves.“The halo effect of the digital showroom in the heart of the city is expected to drive sales to outer stores and potentially affect dealership network setups, both in terms of size and total number of traditional dealerships,” said Frost & Sullivan Director Growth Consulting Automotive & Transportation, Julia Saini.Car companies are also using fashion merchandising and combining lifestyle elements into retailing globally. Lexus Intersect Tokyo and L’ Atelier Renault, Paris conduct special events and exhibitions for new product launches, offering a strong automotive brand experience through lifestyle-related concepts of art, fashion, music, design, food and technology.The advent of digitization in car retailing has led to the development of new and additional performance indicators. It has seen the introduction of innovative sales strategies, and both cost reductions and additions in upfront investments. New KPIs such as brand awareness, digital engagement of customers, customer age, lead response time, and vehicle configurability satisfaction will be of increasing importance in future digital retail formats.“Better quality leads and easier follow-ups through integrated social media strategy define the success of digital showrooms,” noted Saini. “By 2016, automakers are expected to open more than 100 digital showroom/lifestyle stores globally, specifically aimed at enhancing both the retail and brand experience with limited on-floor physical inventory.”With European and North American OEMs expected to invest between $500 million and $5 billion in updating store technology, training staff, and digitally integrating various aspects of the car retailing process, soft digitisation technologies such as digital tools, signage and kiosks are anticipated to grow strongly in the short term.

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FDA Cleared New Application for Simbionix PROcedure Rehearsal Studio

Posted by fidest press agency su sabato, 25 febbraio 2012

Cleveland (PRNewswire) Simbionix USA Corporation, the world’s leading provider of medical education and simulation training, is pleased to announce that Simbionix received FDA clearance for the EVAR (Endovascular Aneurysm Repair) application for the PROcedure Rehearsal Studio™ (PRS). Last year Simbionix received clearance for the PRS Carotid Intervention application. The PROcedure Rehearsal Studio transforms the patient’s CT scan into a 3D visualization model. Simbionix has developed a revolutionary technology to use this 3D visualization model within its endovascular simulator, the ANGIO Mentor, to allow surgeons to evaluate endovascular surgical treatment options before surgery. PRS provides a 3D model of the patient’s vasculature and true-to-life vessel measurement tools. After exporting the 3D model into the ANGIO Mentor simulator practice environment, the physician is able to train and practice aneurysm repair on the patient’s specific anatomy. For the first time, surgeons can practice endovascular abdominal aortic aneurysm repair, including precise deployment of the bifurcated and contralateral leg stent graft, deployment of iliac and aortic extensions and touch-up ballooning. According to Dr. Yael Friedman, Director of Regulatory Affairs for Simbionix, the Simbionix track record in advanced medical education and training is unmatched, with more than 140 studies documenting the effectiveness and value of Simbionix medical simulators. “Based on this foundation, and on quality control, development, and production processes that were put in place over the past few years, we are pleased to be able to move beyond training and also provide the market with a clinical tool,” Dr. Friedman said. “We are very proud that the FDA has cleared the EVAR application and continues to recognize the clinical component of the PROcedure Rehearsal Studio.”
Simbionix is the world’s leading provider of simulation, training and education products for medical professionals and the healthcare industry. The company is committed to delivering high quality products, advancing clinical performance and optimizing procedural outcomes. Visit:

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The European Economic Model

Posted by fidest press agency su mercoledì, 25 gennaio 2012

The European growth model has been an engine for economic convergence during the past few decades and has delivered prosperity to hundreds of millions of people on the continent, says a new World Bank report “Golden Growth: Restoring the Luster of the European Economic Model”, launched today in Brussels. The newreport looks at long-term growth in Europe, paying special attention to the last two decades, and identifies what needs to be done to assure continued prosperity in the decades ahead. It assesses the six principal components of the European growth model: trade, finance, enterprise, innovation, labor, and government. Its main findings: most countries in Europe are doing well in trade and finance, many in enterprise and innovation, but few are doing well in labor and government. So Europe needs many changes to make governments and labor markets work better, fewer changes to foster innovation and productivity growth in enterprises, and fewer changes still to reform finance and trade. Stalled productivity, declining populations, and unsustainable fiscal imbalances have made many changes urgent.* To revitalize the European growth model, the report makes three sets of recommendations: restart the convergence machine that has allowed poorer countries become high income economies; rebuild “brand Europe” that has helped the region, with one-tenth of the world’s population, account for a third of the global economic output; and reassess what it takes to remain the world’s lifestyle superpower, with the highest quality of life on the planet.
Between 1950 and 1973, Western European incomes converged towards those in the United States. Then, until the early 1990s, the incomes of more than 100 million people in the poorer southern periphery—Greece, southern Italy, Portugal, and Spain—converged to those of advanced Europe. Starting with the first association agreements with Hungary and Poland in 1994, another 100 million in Central and Eastern Europe were absorbed into the European Union. Another 100 million in the candidate countries in Southeastern Europe are now benefiting from the same aspirations and similar institutions that have helped almost half a billion people achieve the highest standards of living. If European integration continues, the 75 million people in the Ukraine and other countries of the Eastern Partnership will profit in similar ways.Trade and financial integration are two of the strongest attributes of the European economic model. According to the report, the adjustments needed to strengthen these components are: better management of financial flows, quicker expansion of the modern services trade, and greater mobility of workers.
Europe is known for its combination of engineering and design. Since the mid 1990s, while Asia had a financial crisis and recovery and the United States had a technology boom and financial crisis, European enterprise has flourished. With few exceptions, every part of Europe has seen a growth in employment, productivity, and exports. But during the last decade, two growing shortfalls in productivity are threatening Europe’s global economic influence. The first is that since the mid-1990s, labor productivity in Europe’s leading economies has fallen relative to the United States and Japan. The productivity gap between advanced Europe and the United States today is more than twice what it was in the mid-1990s. The second is that enterprises in southern Europe have become less productive. To be competitive, productivity should have grown by about 3-4 percent each year during the 2000s. Instead, it fell by about 1 percent each year.

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National Model United Nations (NMUN)

Posted by fidest press agency su giovedì, 18 novembre 2010

Perugia 19 novembre prossimo (ore 10:30), presso la Sala Goldoniana dell’Università per Stranieri è convocata una Conferenza Stampa di presentazione del Progetto di simulazione diplomatica per studenti universitari, National Model United Nations (NMUN), organizzato dal Dipartimento di Cultura Generale delle Nazioni Unite.  Verrà illustrata, nello specifico, l’iniziativa <<Consules – Università per Stranieri di Perugia 2011>>, programma di partecipazione al NMUN per gli iscritti dell’ateneo di Palazzo Gallenga.  Il Programma prevede la selezione di 12-16 studenti dell’ateneo, la loro partecipazione ad un corso di formazione pratico-teorica della durata di 3 mesi, e lo svolgimento di uno stage che avrà luogo nella città di New York (USA) dal 15 al 25 aprile 2011. Partners del progetto, insieme all’Università per Stranieri di Perugia, sono l’Associazione Consules, organizzazione no profit a vocazione internazionale che si occupa dello sviluppo e della realizzazione di programmi formativi rivolti a giovani, e la Banca di Credito Cooperativo Perugia, sponsor dell’iniziativa. Illustreranno il progetto il prof. Emidio Diodato

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Raul Ortega Ayala

Posted by fidest press agency su giovedì, 2 aprile 2009

raul1Rokeby Gallery 37 Store Street – London until 2/5/09 An Ethnography on Gardening Raul Ortega Ayala’s art focuses on varied habitual themes which he explores through a detailed and absorptive process. Once this process of direct exploration is over, he uses the materials and experiences that he encounters to produce a group of works which the artist calls, souvenirs.  Having spent over two years working as a gardener in London the artist’s new series of work entitled, An Ethnography on Gardening, will feature a selection of artworks which were first presented at his solo exhibition at the Museo Experimental El Eco, Mexico in December 2008. Through positioning himself as a practicing gardener within a team employed in both private and public spaces in London Ortega Ayala covertly undertook research into the world of gardening. Enabling him to take this culture as his subject he embarked upon an interdisciplinary and contextual approach to fieldwork in the everyday. The series of work that stems from the artists time as a practicing gardener is spilt into groups such as, The Public and Private, From the Imaginary to the Monstrous and Control and Compartmentalization; referring to the artists experiences and past histories associated with gardening as a cultural phenomenon.  If an ethnographic model tends to adopt the role of both cultural observant and assimilation into the world in which you are studying, Ortega Ayala does this by deliberately immersing himself in these conditions, engaging in the uncertainty of proximity and critique. Utilising a variety of media, the materials and issues raised by his work, are driven by the context in which they are set. A progression from the traditional ethnographic model, where the subject is turned into objects and then theory, Ortega Ayala transforms the context into his subject and produces complex enquiries and statements that infer his concomitant relationship to a certain field. By referring to the works as souvenirs, he allures to curio as documentation and display, interrogating representation and the (re)presentation of artistic enquiry. As a Mexican employed for the duration of this project in the UK the immersive process of working as a gardener raised questions about the artist as ethnographer but also as immigrant, allowing a double sense of alterity and self-reflexivity for the artist. Thematics of the hybrid, access and observational rigour are played out in the exhibition within a practice that inherently examines the source and experience of knowledge, whilst questioning the spatial models of interior and exterior occupancy. Ortega Ayala was born and currently lives and works in Mexico, he completed his MA at Glasgow School of Art and Hunter College, New York in 2003, he has exhibited both in the UK and internationally, with solo exhibitions both in London and Mexico City. He will exhibit in At Your Service, an exhibition curated by Cylena Simonds at the David Roberts Art Foundation, Fitzrovia in April 2009. (photo raul)

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