Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 34 n° 296

Posts Tagged ‘patients’

Da Janssen e Altems ‘Raise the patients’ voice’

Posted by fidest press agency su martedì, 21 settembre 2021

La pandemia ha messo a dura prova il nostro sistema salute, facendo emergere il bisogno di includere nella costruzione di nuove e più efficienti soluzioni la voce di tutti gli interlocutori. Da questa premessa nasce il progetto ‘Raise the patients’ voice’, presentato da Janssen in collaborazione con Altems (Economia Università Cattolica, Roma): un corso di alta formazione sulla comunicazione istituzionale realizzato per rispondere al bisogno da parte delle associazioni pazienti di comunicare in maniera efficace con le istituzioni. In particolare, hanno rappresentato addirittura il 42% delle attività messe in campo dalle associazioni durante l’emergenza Covid-19, per proporre e sollecitare i soggetti pubblici ai fini dell’erogazione di alcuni servizi utili per la gestione della propria patologia. Storicamente le associazioni dedite all’advocacy dei pazienti hanno progressivamente assunto una rilevanza sempre più strategica all’interno del Sistema sanitario italiano, soprattutto grazie allo spirito di collaborazione con le istituzioni, così come ad alleanze tra le associazioni per promuovere azioni comuni, disegnare insieme il futuro e porsi come veri e propri agenti di cambiamento del sistema. Al progetto hanno aderito le seguenti associazioni di pazienti: Ail Onlus; Fms Onlus; Europa Donna; Europa Uomo; Incontra Donna; Salute Donna Onlus; Ropi-Rete Oncologica Pazienti Italia; Walce-Women Against Lung Cancer in Europe; Associazione Palinuro; Milano Check Point; Nps Italia Onlus. Network Persone Sieropositive; Associazione Lorenzo Perrone Onlus; Nadir Onlus; Lila Milano; Cittadinanzattiva; Aicca; Aipi; Amici Lazio; Amip; Apiafco; Apmarr; As.Ma.Ra; Gils; Niemann Pick Onlus; Fondazione Onda; Uniamo; Anap; Retina Italia onlus; Fondazione Near e Arcigay. (fonte:

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Hyperfine and Penn Medicine Announce Partnership to Image Hydrocephalus Patients

Posted by fidest press agency su venerdì, 6 dicembre 2019

Hyperfine Research Inc. has joined with Penn Medicine in a clinical research study of the world’s first portable, low-cost magnetic resonance imaging (MRI) system. This collaboration will examine the efficacy of the Hyperfine device in the care of patients with hydrocephalus. Penn Medicine is among the very first medical centers to use this FDA 510(k)-pending system. In addition to assessing the feasibility of imaging patients with the new device, the Penn Medicine team will be evaluating the Hyperfine system’s diagnostic performance compared to current high field MRI machines and computed tomography (CT) scanners. Hydrocephalus is a medical condition in which an abnormal buildup of cerebrospinal fluid (CSF) causes the fluid-filled spaces of the brain to become enlarged. This can lead to headaches, dizziness, cognitive impairment, gait disturbances, and in severe cases, even brain herniation or death.The Hyperfine point-of-care (POC) device represents multiple innovations in MRI design, architecture and workflow. It is highly portable and wheels directly to the patient’s bedside, plugs into a standard electrical wall outlet, and is controlled via an iPad®. Hyperfine’s system was developed over the last five years with the goal of making MRI accessible anytime, anywhere, to any patient.”Hyperfine was founded to increase access to MRI, to move MRI directly to the frontlines of clinical care. Along the way, we have overcome many engineering, physics and design challenges, and now, together with Penn Medicine, we are excited and honored to see how these efforts can translate to innovative care and greater access for patients,” said Jonathan Rothberg, PhD, founder and chairman of Hyperfine Research.Hyperfine is introducing its POC MRI system to the broader radiologist community at the Radiological Society of North America (RSNA) meeting on December 1 through December 5 at McCormick Place in Chicago, IL, Booth 7765 (North Hall). Hyperfine’s device is currently 510(k)-pending and not available for sale in the U.S.

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COPD Outcomes Improved Significantly When Patients and Doctors Used a Digital Health Tool, Propeller Health Study Finds

Posted by fidest press agency su giovedì, 28 novembre 2019

Patients with chronic obstructive pulmonary disease (COPD) at Louisville’s JenCare Senior Medical Center, a ChenMed company, saw their health outcomes improve significantly when their primary care physicians (PCPs) encouraged using Propeller’s digital health tool to manage their COPD, reports new research by Propeller Health, JenCare, ChenMed, and the Center for Healthy Air, Water and Soil investigators published in JMIR Formative Research.
For this study, 190 patients with COPD were given access to Propeller’s digital health tool, which works by attaching a small sensor to a patient’s existing inhaler. Propeller collects data on medication use and sends medication reminders, progress reports and disease insights to the patient’s smartphone or hub, as well as reports to their doctor. The JenCare patients participated as part of the larger AIR Louisville program, which was a collaborative effort to address respiratory disease in Jefferson County, built on partnerships with Mayor Greg Fischer, multiple city agencies, an environmental institute, and local health systems, payers, employers and community groups.
JenCare study participants worked closely with their clinicians to enroll in the program. Clinicians then leveraged real-time data points from Propeller to recommend adjustments to their patients’ personalized care plans.Patients were monitored over the course of 12 months. At three, six and 12 months, patients demonstrated significant reductions in daily rescue medication use and nighttime rescue medication use, as well as an increase in days without symptoms necessitating rescue use. Over the course of 12 months, daily use of rescue medication decreased by 59% and days without symptoms necessitating rescue use increased by 36%. COPD is the fourth leading cause of death in the United States and is predicted to become the number three cause of death globally by 2030. The disease is associated with progressive loss of lung function and has significant impacts on patients’ physical and mental well-being.
Compared to previous studies, which have shown that digital health engagement may fall off after three months, this study showed 81% retention and 90% engagement in patients at the six-month mark, suggesting that digital health tools are particularly effective at keeping patients engaged long-term when a clinical care team is involved. JenCare patients average 208 minutes yearly of face-to-face time with their primary care doctor, more than 10 times the national average, a level of interaction that may have enhanced patient compliance and study outcomes in this study.

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Arthritis Patients Make Multidimensional Treatment Choices, Studies Show

Posted by fidest press agency su martedì, 12 novembre 2019

CreakyJoints®, a Global Healthy Living Foundation patient community, will present five posters, some in partnership with major academic institutions, at the 2019 ACR/ARP Annual Meeting in Atlanta, GA (Nov. 8-12, 2019) that speak to the decisions patients make when treating and tracking their arthritis. In the poster “Legal Matters: Attitudes Regarding Marijuana for Medical Use Among Patients with Rheumatic and Musculoskeletal Disease” (November 12, 2019 from 9-11am ET), an ArthritisPower® research registry study reports that among people with arthritis responding to a survey (n=1,059 participants) who use marijuana for medical use (MMU, 37%), the majority (77%) live in a state where marijuana is legal for medical reasons, though only 40 percent have an actual medical marijuana card to legally purchase it. Among the respondents who had never used MMU (63%), illegality (40%), potential impairment (24%), and not knowing where (21%) or how (20%) to obtain MMU (legally or not) were cited as top reasons for not using it. Of respondents who live in states where marijuana is medically legal, most (68%) had informed their health care provider (HCP) about their MMU use, whereas only slightly more than half (54%, p=0.02) informed their HCP in non-legal states.
Utilizing the ArthritisPower® research registry, which now includes more than 22,000 consented participants, the 77-item survey included 1,059 participants in the United States who were over the age of 18 and reported physician-diagnosed rheumatic or musculoskeletal disease. The survey also required participants to report their current health status (NIH PROMIS Global Health), their use and perceptions of MMU and cannabidiol (CBD) products, and their related information needs. CreakyJoints independently funded this study.

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Access for More Patients™ Transforms Patient Access to Specialty Medications

Posted by fidest press agency su domenica, 29 settembre 2019

RxCrossroads by McKesson and CoverMyMeds today announced the launch of AMP: Access for More PatientsTM, a first-in-class, technology-driven patient support solution that transforms how patients access, afford and adhere to their medications. Designed to automate access to specialty medications for physicians and patients, this collaboration brings together the robust technology platform and established provider network of CoverMyMeds with the deep specialty experience and commercialization expertise of RxCrossroads by McKesson.
Innovative therapies designed to treat complex and chronic specialty diseases continue to reach the market1, growing from fewer than 30 specialty medications approved by the FDA in the early 1990s to more than 400 today2,3. The traditional hub model that helps enroll an average of one in five patients into specialty medication access programs has complex requirements and time-consuming manual processes, which, on average, delay treatment by up to eight weeks.Fundamentally changing the way patient support is provided, the proprietary AMP solution enables four out of five patients across the United States to access their specialty medications 27 percent faster than traditional hub programs. By integrating directly into the physician workflow, AMP enables patients to enroll into biopharma-sponsored patient support programs at the point of prescribing, in real-time before the patient leaves the provider’s office. Results published today in an AMP case study found AMP’s ability to capture patient consent in the provider’s office also helped increase patient enrollment completion by 92 percent. AMP also provides high-touch services for patient cases that need intervention support beyond the automated technology platform, such as proactive clinical support, behavioral coaching and financial assistance. These patient-centric programs improve adherence to medication regimens by an average of 10 percent6, helping to support better outcomes for patients. AMP also helps patients manage reimbursement issues, incomplete benefits information, payment denials and appeals, and other exceptions to enable optimal access to medications.

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To Treat Patients Suffering From Spinal Conditions

Posted by fidest press agency su sabato, 21 settembre 2019

Chicago, September 25-28 the North American Spine Society’s annual meeting where a full display of the lateral surgical systems, including Oro, will be featured. CoreLink, LLC, a leading designer and manufacturer of spinal implant systems, today announced the introduction of the Oro™ Lateral Plate System designed for optimum versatility to treat patients suffering from degenerative disk disease, spondylolisthesis, trauma, or spinal deformities. The CoreLink Oro Lateral Plate System has received first of its kind FDA clearance as the only lateral plating system on the market with the flexibility to be used as supplemental fixation in multiple scenarios to allow optional permanent connection to a CoreLink lateral interbody or for use with an alternative lateral interbody. The Oro Lateral Plate System, or Oro, is a lumbar supplemental fixation device designed to provide temporary stability until fusion is achieved. This low-profile plate can attach to CoreLink’s CL5 PEEK or F3D lateral interbodies at one or two contiguous levels without the need for additional lumbar fixation, such as pedicle screws. F3D implants leverage the company’s proprietary Mimetic Metal™ technology, a state-of-the-art titanium alloy 3D printing process that emulates key characteristics of natural bone. With a trabecular structure of interconnected pores and a directional lattice perimeter for anisotropic load sharing, Mimetic Metal provides an optimal balance between biomechanical performance and imaging characteristics.

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New Report: ndp analytics Urges No More Surprises for Patients

Posted by fidest press agency su venerdì, 6 settembre 2019

With concern over surprise medical bills nearing a tipping point nationwide, ndp analytics, a strategic economic and communications research firm, announced today the release of its latest report, “An Assessment of the CBO Cost Estimate of S. 1895: The Unintended Economic Consequences of the Proposed Price Control System”. This timely research cautions against the rate setting mandate contained in S. 1895, legislation recently introduced in the U.S. Senate called the Lower Health Care Costs Act. While the bill aims to address these unexpected healthcare costs, its actual outcomes would be bleak. The legislation would not only allow government to fix healthcare prices, but also place undue burdens on doctors, hospitals, and most importantly, patients.According to Dr. Nam Pham, managing partner at ndp analytics and co-author of the report, “One out of every two adults in America has opened their mail in disbelief due to one of these surprise charges. Thankfully, there is almost unanimous consent among policymakers and regulators that something must be done. Yet this Senate legislation, which proposes to use a median in-network rate as the benchmark for out-of-network providers, is not the answer. This approach will drain the number of practicing physicians, reduce the quality of care, and increase costs.” The report also highlights examples of better alternatives to curb surprise medical bills. ndp analytics’ Mary Donovan, the report’s other co-author, states, “It is important to note that some models, such as New York’s, have already made strides on this issue. For example, the state uses a neutral database unaffiliated with any one insurance company to define costs. It also uses the independent dispute resolution system that relies on market – not government – based rates. This works for all parties – insurers, doctors, and patients alike.”

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“Patients’ Perceptions and Use of Medical Marijuana”

Posted by fidest press agency su lunedì, 22 luglio 2019

The Global Healthy Living Foundation urges 2020 Presidential candidates to support the rescheduling of marijuana so that it, along with CBD products, can be tested under controlled parameters and with peer review to assess their safety, dosing, and effectiveness, arming both patients and doctors with the best available evidence to make informed treatment decisions. Presently, cannabis remains illegal and classified as a Schedule 1 drug under federal law (defined as being “of no medical use”). Following passage of the 2018 Farm Bill, however, which legalized the regulated production of hemp, along with 33 U.S. states that have legalized the usage of marijuana for medical purposes, many chronic disease patients are trying tetrahydrocannabinol (THC) and cannabidiol (CBD) products to treat serious conditions, such as rheumatic and musculoskeletal disease.
According to the “Patients’ Perceptions and Use of Medical Marijuana” study conducted and presented by CreakyJoints®, a Global Healthy Living Foundation patient community, 57 percent of arthritis patients have reported trying marijuana and/or CBD products for medical purposes. Despite the study finding that 62 percent of those who use marijuana medically regularly use it at least once daily, a third of regularly using participants chose not to tell their healthcare provider about their use of these substances.
It’s time to reschedule marijuana so that it can be studied with the same rigor as other treatments and we urge 2020 Presidential candidates to make this an important objective of their healthcare platform,” he added.To help inform medical decisions, the Global Healthy Living Foundation also asks that the U.S. Food and Drug Administration (FDA) develop and approve clinical trials and conduct proper research to provide doctors and patients with adequate data on the effects of THC and CBD on arthritis and other conditions.

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Treatment of Patients with Acute Graft-Versus-Host Disease

Posted by fidest press agency su domenica, 26 Maggio 2019

Incyte Corporation (Nasdaq:INCY) today announced that the U.S. Food and Drug Administration (FDA) has approved Jakafi® (ruxolitinib) for the treatment of steroid-refractory acute GVHD in adult and pediatric patients 12 years and older. Jakafi is the first and only FDA-approved treatment for this indication.The approval was based on data from REACH1, an open-label, single-arm, multicenter study of Jakafi in combination with corticosteroids in patients with steroid-refractory grade II-IV acute GVHD. Of the 71 patients recruited into REACH1, 49 patients were refractory to steroids alone, 12 patients had received two or more prior anti-GVHD therapies and 10 patients did not otherwise meet the FDA definition of steroid-refractory. Jakafi was administered at 5 mg twice daily, and the dose could be increased to 10 mg twice daily after three days in the absence of toxicity.The efficacy of Jakafi was evaluated based upon Day 28 overall response rate (ORR), defined as a complete response (CR), very good partial response or partial response based on the Center for International Blood and Marrow Transplant Research (CIBMTR) criteria. The Day 28 ORR in the 49 patients refractory to steroids alone was 57 percent with a CR rate of 31 percent. The most frequently reported adverse reactions among all 71 study participants were infections (55 percent) and edema (51 percent), and the most common laboratory abnormalities were anemia (75 percent), thrombocytopenia (75 percent) and neutropenia (58 percent).GVHD is a condition that can occur after an allogeneic stem cell transplant (the transfer of stem cells from a donor) where the donated cells initiate an immune response and attack the transplant recipient’s organs, leading to significant morbidity and mortality. There are two major forms of GVHD, acute and chronic, that can affect multiple organ systems including the skin, gastrointestinal (digestive) tract and liver. Patients who develop steroid-refractory acute GVHD can progress to severe disease, with one-year mortality rates of approximately 70 percent. Previously, the FDA granted Jakafi Breakthrough Therapy Designation and Orphan Drug Designation for the treatment of patients with steroid-refractory acute GVHD, and the supplemental New Drug Application (sNDA) was reviewed under the FDA’s Priority Review program.Jakafi will be made available to appropriate patients with steroid-refractory acute GVHD immediately. Incyte is committed to supporting patients and removing barriers to access medicines. Eligible patients in the U.S. who are prescribed Jakafi have access to IncyteCARES (Connecting to Access, Reimbursement, Education and Support), a comprehensive program offering patient support, including financial assistance and ongoing education and resources to eligible patients.

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Dentists Are Often the First to Find Possible Signs of Oral Cancer in Patients

Posted by fidest press agency su domenica, 19 Maggio 2019

Dental checkups are critical for healthy and long-lasting teeth, but they can also help with the detection of serious and even life-threatening forms of oral cancer.Dentists are often the first to identify growths or suspicious-looking areas in the mouth of patients that could be the first sign of oral cancer – including oral cavity cancer, such as in the lips or tongue, and oropharyngeal cancer, more commonly referred to as throat cancer.
And early detection and treatment as soon as possible are important for defeating oral cancer, which can also occur in the cheeks, lips, gums, tongue, and floor and roof of the mouth.A dentist recently discovered a growth on Gibbs’ mouth during a routine checkup. Gibbs, 26, was diagnosed with salivary gland cancer – a very rare form of cancer that affects about 1 of every 100,000 people, according to the American Cancer Society.
Gibbs, who advanced to the third round of the U.S. Open in 2014 and the Australian Open in 2017, will have surgery Friday and miss the French Open that starts May 26. But Gibbs plans to participate in the qualifying matches for Wimbledon in late June.Gibbs is the latest well-known athlete or entertainer to be diagnosed with oral cancer. Many celebrities, including actor-producer Michael Douglas and guitarist Eddie Van Halen, have battled and defeated oral cancer, thanks to early diagnosis and treatment.Currently, an estimated 91,000 people in the U.S. are living with oral cancer, and about 39,000 new cases are diagnosed every year, according to the National Institute of Health. About 8,000 deaths are connected to oral cancer every year in the U.S. Many of those deaths could be prevented with early diagnosis, according to many reports. The five-year survival rate for oral cancer diagnosed early is 75 percent, but the rate drops dramatically to 20 percent with a late diagnosis, according to the NIH.

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Phase III CAPTAIN Study of Trelegy Ellipta in Patients with Asthma Meets Primary Endpoint

Posted by fidest press agency su domenica, 5 Maggio 2019

GlaxoSmithKline plc (LSE/NYSE: GSK) and Innoviva, Inc. (NASDAQ: INVA) today announced headline results from the pivotal phase III CAPTAIN study of once-daily single inhaler triple therapy Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol: FF/UMEC/VI) compared to Relvar/Breo Ellipta (FF/VI), in the treatment of patients living with uncontrolled asthma.The study met its primary endpoint, demonstrating a statistically significant 110mL improvement in lung function (measured by change from baseline in trough FEV1 at 24 weeks of treatment) for FF/UMEC/VI 100/62.5/25mcg (p<0.001, 95% CI: 66-153 mL) compared with Relvar/Breo 100/25mcg and a statistically significant 92mL improvement in trough FEV1 for FF/UMEC/VI 200/62.5/25mcg versus Relvar/Breo 200/25mcg (p<0.001, 95% CI: 49-135 mL).The key secondary endpoint was annualised rate of moderate/severe exacerbations for FF/UMEC/VI (100/62.5/25 and 200/62.5/25) versus Relvar/Breo (100/25 and 200/25) and demonstrated a 13% (95% CI: -5.2 to 28.1) reduction in exacerbations, however this was not statistically significant. Therefore, all subsequent analyses were considered descriptive.
Dr. Hal Barron, Chief Scientific Officer and President, R&D, GSK, said: “We believe a once-daily single inhaler triple therapy that improves lung function is an advance for patients with uncontrolled asthma since this option is not currently available. We plan to submit these data for regulatory review after the full dataset is available.”CAPTAIN was also designed to investigate two further doses of FF/UMEC/VI (100/31.25/25 and 200/31.25/25 mcg) compared to Relvar/Breo (100/25 and 200/25). There were increases in trough FEV1 of a similar magnitude to those of FF/UMEC/VI 100/62.5/25 and 200/62.5/25, with no difference in exacerbation rates.The safety profile of FF/UMEC/VI was consistent with the known profile of the individual components and their combinations. Adverse event rates were similar across all six study arms with the most common adverse events being reported as nasopharyngitis (13-15%), headache (5-9%), upper respiratory tract infection (3-6%) and bronchitis (3-5%).Dr. Paul Meunier, Vice President of Respiratory Medicine at Innoviva noted that: “The CAPTAIN study has shown that triple therapy in a single inhaler provides a potential new treatment option for asthma management in patients uncontrolled on ICS/LABA.”
Full results from CAPTAIN will be submitted for future presentation at upcoming scientific meetings and in peer-reviewed publications.

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Awareness of Fatty Liver Disease Remains Low Among Most At-Risk Patients

Posted by fidest press agency su domenica, 5 Maggio 2019

The results of a new survey released last week at the 3rd Annual NASH (nonalcoholic steatohepatitis) Summit in Boston show that even among patients most at-risk for the fatty liver disease, awareness of the condition remains low.Global clinical trial enrollment company Continuum Clinical, which conducted the survey, found that among Americans with co-morbidities most associated with NASH—including type 2 diabetes, obesity, and hypertension—only 6% have ever heard of NASH. In a previous survey Continuum conducted of 1,000 Americans, unaided awareness of NASH was only 2%.”Low public awareness of NASH and fatty liver disease is a barrier to clinical trial enrollment,” said Cathleen Dohrn, Ph.D., Continuum Clinical’s Senior Scientific Director who presented the findings at the Summit. “NASH clinical trial sponsors need thousands of patients in order to find the first treatment for this condition, which will necessitate increased awareness and diagnosis of NASH.”According to the National Institute of Diabetes and Digestive and Kidney Diseases, NASH is an advanced form of nonalcoholic fatty liver disease (NAFLD), a condition in which excess fat is stored in your liver and is not caused by heavy alcohol use. NAFLD is one of the most common causes of liver disease in the United States, and a precursor to NASH. Experts estimate that about 20 percent of people with NAFLD have NASH.Continuum also found that 48% of at-risk Hispanic/Latino respondents were most concerned about liver disease versus 32% of the total population surveyed. In addition, Hispanic/Latino respondents were more significantly more interested in learning about a hypothetical NASH clinical research study (62% versus 49% of the total population).”NASH disproportionately affects the Hispanic/Latino population, so having confirmation that this cohort is interested in clinical research signals to us that a special effort must be made to ensure clinical trial enrollment is inclusive,” Dohrn said.
To help explore strategies on how pharmaceutical companies can tackle this patient enrollment challenge, on May 22 Continuum Clinical will host a webinar on overcoming NASH clinical trial challenges with Wayne Eskridge, CEO of the Fatty Liver Foundation, and Qin Ye, MD, MS, associate principal of ZS Associates.

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Therapies for Patients with Serious Liver Disease

Posted by fidest press agency su sabato, 15 dicembre 2018

Perspectum Diagnostics and the SC Liver Research Consortium (SCLRC) are delighted to announce a collaboration to advance clinical development of investigational therapies. This will focus on patients with serious liver diseases including non-alcoholic steatohepatitis (NASH), primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH) and hepatocellular carcinoma (HCC).SCLRC is a site management organization consisting of over 85 clinical sites based in the United States with specialized expertise in hepatology. SCLRC has successfully executed phase 1-3 trials in hepatitis C, hepatitis B, NASH, cirrhosis and HCC. SCLRC offers sponsors guidance in clinical development, as well as the recruitment and execution of clinical trials for regulatory approvals.Perspectum are imaging experts in Magnetic Resonance Imaging (MRI) and provide specialized imaging clinical research services in NASH, cholestatic liver disease and HCC. Their products, LiverMultiScanTM (which includes MRI-PDFF) and MRCP+, for quantitative imaging of the liver and biliary tree, and their comprehensive imaging CRO services have been included in over 18 phase 1-3 studies since their launch in 2014.With these complementary offerings, SCLRC and Perspectum will build a major US-based network setting a new standard for sponsors, both Pharmaceutical and Biotech companies. This network will be focused on clinical development of drugs and diagnostics for patients with liver disease. SCLRC currently has 45 clinical sites with access to Perspectum’s imaging-technology, with plans to enable the majority of clinical sites by June 2019.“We believe that this unique partnership will bring together novel technologies with deep clinical development experience to address high unmet medical needs for patients with liver disease,” according to Dr Cathy O’Hare, Head of US operations for Perspectum, based in South San Francisco. Professor Sir Michael Brady, Chairman of the Perspectum Board went further: “Perspectum Diagnostics, with technology that builds on decades of academic research at the University of Oxford, is changing the paradigm for clinical development in liver disease. We have the opportunity to develop drugs for diseases that to date have had no approved therapies, because we have the unique ability to demonstrate the benefits of investigational agents on imaging biomarkers.” Dr. Paul Pockros, Head of SCLRC and the Director of the Liver Disease Center at Scripps Clinic comments: “The collaboration between SC Liver Research Consortium and Perspectum will provide investigators and sites with an important technology to allow breakthroughs in NASH research. We believe this relationship will be beneficial for patients and physicians alike.”

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Patients Search for Information Online

Posted by fidest press agency su lunedì, 10 settembre 2018

Recent research commissioned1 by Teva Pharmaceuticals has shown that patients, especially those with chronic conditions, have a significant need for online information but they question the reliability of some sources.
Today, Teva in Europe announced a series of partnerships and initiatives aimed at directly addressing this unmet need. The first, a partnership with Healint, the developer of the Migraine Buddy© platform, will provide real-world evidence about the many issues and outcomes experienced by migraine patients in Europe. These statistical insights produced by Healint on their platform are based on the contributions of patients, who opt-in to share about their condition anonymously for the purpose of increased migraine awareness, and research. This patient-reported evidence with an unprecedented scale will support the generation of educational and supportive content for doctors, neurologists, health specialists and individuals looking to enhance their understanding of migraine.Recent research in the professional field highlights the growing interest by medical professionals in digital assets to support their continuous education needs and day-to-day work. A 2017 DRG Digital report found that millennial physicians are more reliant on digital sources of information spending as much as three hours consulting external digital resources including websites for healthcare professionals. They source online medical journals and medical reference sites far more frequently than their older peers. To address this professional need Teva is working with Migraine Trust International Symposium (MTIS) to create engaging online interviews with leaders in the field of neurology including Professor of Neurology at King’s College London and Medical Trustee of The Migraine Trust, Peter J. Goadsby on the subject of ‘Recent advances in headache neuroimaging’. These videos and content will be made available through the MTIS website for UK delegates and on for non-UK delegates.
Neurology Bytes is a European Healthcare Professional portal initiated by Teva Europe that hosts a variety of educational content that complements the busy schedule of a neurologist and addresses the unmet need for reliable and trustworthy information.Teva Head of Digital, Timothy White said: “Teva is committed to empowering patients and professionals around the world through their health journey, especially those living with or treating chronic conditions such as migraine, by providing high quality medicines as well as tools based on human insights. Our partnerships with MTIS and Healint as well as the growth of our platform demonstrate the practical ways of how we are bringing the vision to life.”

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Heart doctors call for permission to provide therapy to stroke patients

Posted by fidest press agency su venerdì, 25 Maggio 2018

Paris, France Heart doctors from the European Society of Cardiology (ESC) Council on Stroke are calling on national health authorities for permission to provide stroke patients with mechanical thrombectomy, a life-saving treatment for acute ischaemic stroke, in regions where there is a lack of trained specialists. Details of the proposal are presented today at EuroPCR 2018.1“We have evidence that after a short period of training on the procedure, interventional cardiologists treating acute ischaemic stroke achieve the same results as traditional interventional neuroradiologists,” said Professor Petr Widimsky, Chair of the ESC Council on Stroke.Acute ischaemic stroke is a severe form of the condition where a blood vessel to the brain becomes blocked. It accounts for up to four in five strokes, or over one million cases in Europe each year.Without treatment most patients die or are severely disabled and permanently bedridden. Even with clot-busting drugs, 75% of patients die or are severely disabled. With mechanical thrombectomy, a procedure to physically remove the clot and restore blood flow to the brain, about half of patients survive and function normally. If performed within two to three hours of symptom onset, the rate of survival with normal neurological function rises to more than 70% of patients.In Europe, mechanical thrombectomy is currently provided by interventional neuroradiologists, but there is a severe shortage of these specialists. Even countries with the most specialists, such as Germany, the Netherlands and the Czech Republic, only have sufficient numbers to treat around one-third of acute ischaemic stroke patients. In some other countries, less than 1% of acute ischaemic stroke patients can be treated.Professor Widimsky said: “There are interventional cardiology units in all countries in Europe and the Americas, and in most other continents. The equipment for mechanical thrombectomy is available; it’s the trained specialists to perform the procedure that are lacking. This situation could be solved by training cardiologists to perform mechanical thrombectomy.”The ESC Council on Stroke is proposing that interventional cardiologists receive three months of training on how to do mechanical thrombectomy, rather than the typical two years required for other physicians. “Many interventional cardiologists routinely perform stenting of the carotid arteries so three months of training is sufficient to learn intracranial mechanical thrombectomy,” said Professor Widimsky. “It is up to health authorities in each country to decide if they will allow this.”
The proposals are being put forward by the ESC Council on Stroke and the European Association of Percutaneous Cardiovascular Interventions, a branch of the ESC.

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Faster walking heart patients are hospitalised less

Posted by fidest press agency su sabato, 21 aprile 2018

Ljubljana, Slovenia. Faster walking patients with heart disease are hospitalised less, according to research presented today at EuroPrevent 2018, a European Society of Cardiology congress, and published in the European Journal of Preventive Cardiology.1,2
The three-year study was conducted in 1,078 hypertensive patients, of whom 85% also had coronary heart disease and 15% also had valve disease.Patients were then asked to walk 1 km on a treadmill at what they considered to be a moderate intensity.3 Patients were classified as slow (2.6 km/hour), intermediate (3.9 km/hour) and fast (average 5.1 km/hour). A total of 359 patients were slow walkers, 362 were intermediate and 357 were fast walkers.
The researchers recorded the number of all-cause hospitalisations and length of stay over the next three years. Participants were flagged by the regional Health Service Registry of the Emilia-Romagna Region, which collects data on all-cause hospitalisation.Study author Dr Carlotta Merlo, a researcher at the University of Ferrara, Ferrara, Italy, said: “We did not exclude any causes of death because walking speed has significant consequences for public health. Reduced walking speed is a marker of limited mobility, which is a precursor of disability, disease, and loss of autonomy.” 4,5. During the three year period, 182 of the slow walkers (51%) had at least one hospitalisation, compared to 160 (44%) of the intermediate walkers, and 110 (31%) of the fast walkers.
The slow, intermediate and fast walking groups spent a total of 4,186, 2,240, and 990 days in hospital over the three years, respectively.The average length of hospital stay for each patient was 23, 14, and 9 days for the slow, intermediate and fast walkers, respectively (see figure).
Each 1 km/hour increase in walking speed resulted in a 19% reduction in the likelihood of being hospitalised during the three-year period. Compared to the slow walkers, fast walkers had a 37% lower likelihood of hospitalisation in three years.Dr Merlo said: “The faster the walking speed, the lower the risk of hospitalisation and the shorter the length of hospital stay. Since reduced walking speed is a marker of limited mobility, which has been linked to decreased physical activity,4 we assume that fast walkers in the study are also fast walkers in real life.”
She continued: “Walking is the most popular type of exercise in adults. It is free, does not require special training, and can be done almost anywhere. Even short, but regular, walks have substantial health benefits. Our study shows that the benefits are even greater when the pace of walking is increased.”

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Stroke prevention drugs may help reduce dementia risk for atrial fibrillation patients

Posted by fidest press agency su domenica, 18 marzo 2018

Barcelona, Spain – Patients with atrial fibrillation could reduce the risk of dementia by taking stroke prevention medications, according to recommendations published online today in EP Europace1, a European Society of Cardiology journal, and presented at EHRA 2018.2 The international consensus document was also published in HeartRhythm, the official journal of the Heart Rhythm Society (HRS), and Journal of Arrhythmia, the official journal of the Japanese Heart Rhythm Society (JHRS) and the Asia Pacific Heart Rhythm Society (APHRS).The expert consensus statement on arrhythmias and cognitive function was developed by the European Heart Rhythm Association (EHRA), a branch of the European Society of Cardiology (ESC); the Heart Rhythm Society (HRS); the Asia Pacific Heart Rhythm Society (APHRS); and the Latin American Heart Rhythm Society (LAHRS).Heart rhythm disorders (arrhythmias), as well as some procedures undertaken to treat them, can increase the risk of cognitive decline and dementia. The international consensus document was written for doctors specialising in arrhythmias and aims to raise awareness of the risks of cognitive impairment and dementia and how to reduce them.The document states that atrial fibrillation is associated with a higher risk for cognitive impairment and dementia, even in the absence of apparent stroke. This may be because atrial fibrillation is linked with a more than two-fold risk of silent strokes. The accumulation of silent strokes and the associated brain injuries over time may contribute to cognitive impairment.Stroke prevention with oral anticoagulant drugs is the main priority in the management of patients with atrial fibrillation. The consensus document says that oral anticoagulation may reduce the risk of dementia.Adopting a healthy lifestyle may also reduce the risk of cognitive decline in patients with atrial fibrillation. This includes not smoking and preventing or controlling hypertension, obesity, diabetes, and sleep apnoea.“Patients with atrial fibrillation may be able to reduce their risk of cognitive impairment and dementia by taking their oral anticoagulation medication and having a healthy lifestyle,” said Dr Nikolaos Dagres, lead author and consultant, Department of Electrophysiology, Heart Centre Leipzig, Germany.The document also reviews the association between other arrhythmias and cognitive dysfunction, including post-cardiac arrest, in patients with cardiac implantable devices such as implantable cardioverter defibrillators (ICDs) and pacemakers, and ablation procedures.Treatment of atrial fibrillation with catheter ablation can itself lead to silent strokes and cognitive impairment. To reduce the risk, physicians should follow recommendations for performing ablation and for the management of patients before and after the procedure.3,4
The consensus document notes that physicians may suspect cognitive impairment if a patient’s appearance or behaviour changes — for example, if appointments are missed. Family members should be asked for collateral information. If suspicions are confirmed, the consensus document recommends tools to conduct an objective assessment of cognitive function.The paper highlights gaps in knowledge and areas for further research. These include, for instance, how to identify atrial fibrillation patients at increased risk of cognitive impairment and dementia, the effect of rhythm control on cognitive function, and the impact of cardiac resynchronisation therapy (CRT) on cognitive function.

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Heart attack patients prescribed antidepressants have worse one-year survival

Posted by fidest press agency su lunedì, 5 marzo 2018

The observational study of nearly 9,000 patients found that those prescribed antidepressants at discharge from hospital after a heart attack had a 66% greater risk of mortality one year later than patients not prescribed the drugs, although they noted the cause is not necessarily related directly to the antidepressants.Lead author Ms Nadia Fehr, a medical student at the University of Zurich, Switzerland, said: “Previous studies have suggested that cardiovascular disease may increase the likelihood of being depressed. On the other hand, depression appears to increase the probability of developing cardiovascular risk factors. However, little is known about the impact of depression on outcome after a heart attack.”This study assessed the association of antidepressant prescription at hospital discharge with the one-year outcomes of patients with acute myocardial infarction (heart attack).Data from AMIS Plus, the Swiss nationwide registry for acute myocardial infarction, were used to analyse 8,911 heart attack patients admitted to hospitals in Switzerland between March 2005 and August 2016. Patients were followed up by telephone 12 months after discharge.The researchers compared patients who received antidepressant medication at discharge with those who did not with regard to baseline characteristics and one-year outcomes including mortality, a subsequent heart attack, and stroke.A total of 565 (6.3%) patients received antidepressants at discharge from hospital. Compared to those who did not receive the drugs, patients prescribed antidepressants were predominantly female, older, and more likely to have hypertension, diabetes, dyslipidaemia, obesity and comorbidities. They were less likely to undergo percutaneous coronary intervention or receive P2Y12 blockers or statins, and stayed in hospital longer.After adjusting for baseline characteristics the researchers found that the rates of stroke and subsequent heart attacks were similar between the two groups, but patients prescribed antidepressants had significantly worse survival. The rate of all-cause mortality at one-year after discharge was 7.4% in patients prescribed antidepressants compared to 3.4% for those not prescribed antidepressants (p<0.001).Antidepressant prescription was an independent predictor for mortality, and increased the odds by 66% (odds ratio: 1.66; 95% confidence interval: 1.16 to 2.39).“This was an observational study so we cannot conclude that antidepressants caused the higher death rate,” noted Ms Fehr.She concluded: “Our study showed that many patients are treated with antidepressants after a heart attack. More research is needed to pinpoint the causes and underlying pathological mechanisms for the higher mortality we observed in this patient group.”

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Rapid blood vessel scan tolerated by claustrophobic patients unable to stand longer tests

Posted by fidest press agency su domenica, 4 febbraio 2018

arterial and venous anatomyBarcelona, Spain Doctors have developed a new five-minute procedure to scan the blood vessels which offers hope for claustrophobic patients unable to tolerate the conventional longer test. The research is presented at CMR. Magnetic resonance angiography (MRA) is a magnetic resonance imaging (MRI) exam that takes pictures of the blood vessels. Physicians use the images to diagnose diseases of the blood vessels, such as aneurysms or blockages.During the test patients lie on a table inside a tunnel-like tube and must remain still. A dye, called a contrast agent, is injected into the veins so the vessels can be seen more clearly. Patients are given a headset to block out noise from the scanner. An MRA can typically take 30 minutes to one hour, from start to finish.“Lengthy scans can be problematic for patients with even modest levels of claustrophobia who may refuse the test or ask for it to be stopped early,” said Dr Puja Shahrouki, research fellow, David Geffen School of Medicine at UCLA, Los Angeles, US. “They also limit the number of patients that can be scanned each day. In addition, the usual gadolinium-based contrast agents can be an issue for patients with kidney problems.”This study aimed to shorten the scan time and still produce high quality images. The researchers used ferumoxytol as the contrast agent as it stays within the vascular system for much longer than gadolinium-based dyes. With gadolinium-based agents, there is a short time when the images can be taken, which means patients have to wait in the scanner while the clinician watches the dye move through the body in order to capture the images when the dye enters the blood vessels.
The UCLA study included seven claustrophobic patients aged 11 to 63 years with kidney failure. There were four men and three women. All patients said they were reluctant to undergo MRA due to claustrophobia, but agreed to a trial of up to ten minutes in the scanner bore.Eight MRA scans using ferumoxytol were conducted. All scans were completed and there were no adverse events. Scans took an average of 6.27 minutes (range four to ten minutes). All scans were high quality and allowed full visualisation of the arterial and venous anatomy from the neck to the thighs
“Despite being claustrophobic, all patients completed the MRA and the images could be used for diagnosis of the entire vascular system,” said Dr Shahrouki. “Some of the scans were done in less than five minutes once the procedure started, making it much shorter than the tests currently used in medical practice.” The researchers have shown that the test can be used to diagnose venous and arterial diseases, such as central venous occlusion and aneurysms, and to aid preprocedural planning, for example in transcatheter aortic valve replacement. In principle, it is possible to scan several patients in an hour as opposed to just one or two, raising promising possibilities for workflow and efficiency.
Dr Shahrouki said: “This method could enable claustrophobic patients to receive lifesaving diagnoses and procedures. For appropriate types of studies, it could also shorten waiting lists and improve the cost-benefit ratio for hospitals.” The new protocol should be technically easier than current practice because there is no time pressure for taking images. Ferumoxytol is increasingly recognised as an alternate contrast agent in patients with poor kidney function, but is not marketed outside the US. It is approved by the US Food and Drug Administration (FDA) only for the treatment of iron deficiency anaemia in adults with chronic kidney disease.Hypersensitivity reactions have occurred in patients receiving ferumoxytol as a high dose for therapy in a short period of time, and the FDA has warned against this. The new MRA protocol administers the dye by slow infusion outside the MRI machine while monitoring the patient’s vital signs, in compliance with FDA guidelines. A preliminary study showed this was safe2 and a larger registry is generating a safety profile of slow infusion under close monitoring. More safety data will be needed before any conclusions can be drawn about the true rate of hypersensitivity reactions and in the meantime close monitoring is the rule.Dr Shahrouki said: “The protocol could have huge implications for claustrophobic patients and efficient use of scanners. We envisage it being used very widely in patients with a clear clinical indication.” (photo: arterial and venous anatomy)

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Nearly 25% of chronic ischaemic heart disease patients dead or hospitalised in six months

Posted by fidest press agency su mercoledì, 17 gennaio 2018

Sophia Antipolis, Nearly a quarter of patients with chronic ischaemic cardiovascular disease are dead or hospitalised within six months, reports a European Society of Cardiology (ESC) study published today in the European Journal of Preventive Cardiology. “Coronary artery disease is the leading cause of death worldwide yet some patients appear to get lost in the system after their initial visit to a hospital or outpatient clinic,” said lead author Cardiology Professor Michel Komajda, of the University Pierre and Marie Curie and Pitié-Salpêtrière Hospital in Paris, France.
The Chronic Ischaemic Cardiovascular Disease (CICD) Pilot Registry was designed to learn what happens to these patients in the six months after being seen by a health professional. The observational study was conducted as part of the EURObservational Research Programme (EORP) of the ESC.
The study included 2,420 patients from 100 hospitals and outpatient clinics in ten European countries. Participants had stable coronary disease2 or peripheral artery disease, the most common conditions seen by a cardiologist. Risk factors and treatments were recorded at the start of the study and have been previously reported.3 Treatments and outcomes were recorded at six months.
Follow-up data were available for 2,203 patients, of whom 522 (24%) had died or been rehospitalised during the six months. Factors significantly associated with the risk of dying or being rehospitalised were older age, with a hazard ratio (HR) of 1.17 for every ten years, history of peripheral revascularisation (HR 1.45), chronic kidney disease (HR 1.31) and chronic obstructive pulmonary disease (HR 1.42) (all p<0.05). The majority of the causes of death and rehospitalisation were cardiovascular.Professor Komajda said: “These patients are at high risk of dying or being navigatore coronarierehospitalised in the short-term and should be carefully monitored by physicians. We identified clinical factors which are strongly associated with this high risk which can easily be assessed.”
The rate of prescription of angiotensin converting enzyme inhibitors, beta-blockers (both drugs reduce blood pressure) and aspirin was lower at six months compared to the start of the study (all p<0.02).Professor Komajda said: “In absolute numbers the reductions were modest but they did reach statistical significance. This shows that patients have a better chance of receiving recommended medications while in hospital or directly after an outpatient appointment. Six months later, drugs they should be taking to reduce the risk of death and rehospitalisation are prescribed less frequently.”He added: “It is likely that there is insufficient handover of these patients to a cardiologist or GP and so their prescriptions are not renewed.”While the study did not assess the reasons for the reduction in prescriptions, possible factors include: patients getting tired of taking pills or cannot afford them.Six month rates of death and rehospitalisation were significantly higher in eastern, western and northern European countries compared to those in the south. Given the relatively small number of patients, Professor Komajda said firm conclusions could not be drawn. But he said: “We anticipated that outcomes would be better in Mediterranean countries and this was correct, probably because of the diet and other lifestyle reasons.” Professor Komajda concluded: “The study shows that patients with chronic ischaemic cardiovascular disease have a high risk of poor short-term outcomes. Yet some are not receiving recommended preventive medications which could improve their outlook. More efforts are needed to ensure that these patients continue to be monitored and treated after they leave hospital or an outpatient appointment.”

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