Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 31 n° 301

Posts Tagged ‘reduction’

LineaRx and Takis/Evvivax Anti-Cancer Vaccine Candidates Demonstrate Tumor Reduction

Posted by fidest press agency su domenica, 22 settembre 2019

Applied DNA Sciences Inc. (NASDAQ: APDN) (“Applied DNA”), a leader in large-scale PCR-based DNA manufacturing, announced today that LineaRx, Inc. (“LineaRx”), its majority-owned subsidiary focused on next-generation biotherapeutics, and its collaborators Takis/Evvivax have completed pre-clinical animal studies of two vaccine candidates produced with linear DNA. Tests of both vaccines in mouse models demonstrated their ability to eliminate tumors in vivo, and to potentially prevent initial occurrence.
Evvivax S.R.L. designed a synthetic gene sequence to produce immunity in companion animals, directed against the protein telomerase (TERT), which is overexpressed in 85% of all mammalian cancers, whereas Takis S.R.L. designed a neoantigen-based cancer vaccine (TK), as a proof-of-concept of personalized immunology. For the studies, the TERT and TK based vaccines were produced in linear DNA form by LineaRx. Here is a summary of the recently completed studies performed in vivo: Previous results from Phase 1 of the collaboration’s Joint Development Agreement (JDA) confirmed immunogenicity in mice that were vaccinated with linear DNA against the human protein telomerase. The results reported herein are from the Phase 2 of the JDA using mice implanted with murine colon cancer.
In the prophylactic use of the telomerase vaccine, wherein vaccination is done before addition of tumor cell lines to the mice, transplanted tumors were cleared within 10 days.
In the therapeutic application using either TERT or TK linear DNA vaccine application, cancer cells were introduced and allowed to grow before administration of the vaccine. The successful reduction of total tumor mass was accomplished in conjunction with antibodies that targeted PD-1 and CTLA4. These antibodies, known as Checkpoint Inhibitors, are commonly used in oncology strategies that rely upon immunotherapy. In this setting the tumor cells were reduced significantly within 30 days. The strategy of the Takis TK neoantigen vaccine uses unique multiple-target antigenic epitopes that have been identified from the tumor of a human patient. The linear DNA can utilize the genes for several of the most effective universal antigens such as TERT, or neoantigens that are more personalized to the patient.

Posted in Estero/world news | Contrassegnato da tag: , , | Leave a Comment »

Négociations climat 2015: accélérer ou freiner la transition énergétique?

Posted by fidest press agency su martedì, 29 settembre 2015

Paris NightCe Policy paper de Jean-Arnold Vinois et de Thomas Pellerin-Carlin, vise à donner des propositions concrètes en direction des décideurs de l’UE pour faire de la COP21 une étape utile permettant l’atténuation du dérèglement climatique et l’adaptation à ce dernier.
Le dérèglement climatique a déjà commencé. 2014 a été l’année la plus chaude jamais enregistrée dans l’histoire de l’humanité et, jusqu’à présent, 2015 est une année encore plus chaude. Le dérèglement climatique impacte déjà des secteurs clés de l’économie ainsi que la sécurité internationale.La transition énergétique a déjà commencé puisque des acteurs étatiques et non-étatiques ont pris des engagements de réduction de leur empreinte carbone. Pour les dirigeants mondiaux réunis à la COP21, la question est donc simple: accélérer ou freiner la transition énergétique?Malgré ses propos officiels, l’UE ne peut pas imposer au monde son propre cadre réglementaire sous la forme d’un “Protocole de Paris”. L’UE devrait donc concentrer ses efforts sur trois éléments pour faire de la COP21 une étape utile permettant l’atténuation du dérèglement climatique et l’adaptation à ce dernier:Avancer vers la création d’un prix mondial du carbone pour accélérer la transition énergétique et financer le Fonds Vert.Supprimer progressivement la production d’électricité à base de charbon.
Inclure les entreprises et la société civile dans l’atténuement du/ l’adaptation au changement climatique.
Lors de la COP21, le risque est d’adopter un document de 15 pages contenant des déclarations générales et des formules vagues, ce qui ne ferait que freiner la transition énergétique. L’UE doit faire en sorte d’éviter cela et utiliser ses capacités et compétences diplomatiques pour faciliter l’adoption d’une feuille de route pragmatique permettant l’atténuation du dérèglement climatique et l’adaptation à ce dernier, qui accélère la transition énergétique. Pour ce faire, elle doit s’appuyer sur des solutions concrètes qui nous aident à atteindre un idéal clair : l’énergie durable pour tous.

Posted in Estero/world news, Spazio aperto/open space | Contrassegnato da tag: , , , | Leave a Comment »

Food Safety Patent Pending: Pre-harvest reduction of foodborne pathogens in food animals

Posted by fidest press agency su venerdì, 11 settembre 2015

Food_SecurityCedar Rapids, IA Diamond V announces the patent-pending use of Diamond V Original XPC™ as a “method for foodborne pathogen reduction in livestock.” Feeding all-natural Original XPC as recommended during food animal production helps reduce the prevalence and numbers of Salmonella and Campylobacter in the animal, production environment, and food processing plant, as described in the pending patent and supported by numerous scientific studies. Reducing these pathogens pre-harvest can improve food safety.Over 125 peer-reviewed scientific journal articles describe how the pre-harvest technologies of Diamond V products support immunity, health, and performance of poultry, pigs, dairy and beef cattle, aquaculture species, and other food animals. Diamond V technology for pre-harvest reduction of foodborne pathogens deserves attention from all decision makers throughout the food supply chain, including executives, quality assurance personnel, veterinarians, and farmers.Consumers today are concerned about how their food is produced and accept the use of effective, all-natural products. Diamond V’s unique, all-natural, fermentation-based products offer safe, cost-effective, pre-harvest solutions for food animal production.“Our industry-leading research and ‘first in the field’ patent pending pre-harvest pathogen reduction applications give producers and consumers confidence that Diamond V technologies and expertise help provide additional security from food safety challenges,” says Jeff Cannon, Diamond V President and CEO.Diamond V’s pending patent is based on numerous studies at many research institutions that involved pathogenic challenges to healthy animals by several different strains of Salmonella and Campylobacter. The resulting body of scientific knowledge on the effects of Original XPC on foodborne pathogen reduction represents the largest known collection of pre-harvest food safety research projects. These projects are the replicable work of leading investigators using varying methods. The quality, consistency, and reliability of these multiple sources of data further support Diamond V’s unique pending patent.Most efforts to reduce pathogen numbers in food animals and products, including chemicals applied during processing, are not completely effective. Research shows that the pre-harvest pathogen contamination of animals correlates directly with the post-harvest presence of pathogens in food products. Research also indicates that, while there is no “silver bullet” to completely eliminate foodborne pathogens, a multi-step intervention plan — including pre-harvest mitigation at the farm level – is most effective.Original XPC and other Diamond V nutritional health products are manufactured in Diamond V facilities in the USA using proprietary microbial fermentation technologies that generate unique functional metabolites with proven beneficial effects on animal health, performance, and food safety. Scientific references appear in the attached white paper on food safety and are available upon request.Headquartered in Cedar Rapids, Iowa, USA, Diamond V is an international leader in nutritional health products for animals and people, with offices around the world and sales in over 60 countries. More than 70 years of science, innovation, technology, and quality have earned Diamond V the reputation of The Trusted Experts in Nutrition and Health®. The company’s Embria Health Sciences subsidiary in Ankeny, Iowa manufactures EpiCor®, the human nutritional supplement that provides research-proven immune support.

Posted in Estero/world news | Contrassegnato da tag: , , , | Leave a Comment »

Greenpeace reacts to China’s climate plan to the UN

Posted by fidest press agency su mercoledì, 1 luglio 2015

BeijingParis/Beijing. China submitted a carbon intensity reduction targets of 60-65% by 2030, based on 2005 levels, to the UN as part of its climate plan (INDC). The announcement came as Chinese premier Li Keqiang was in Paris for an official visit to France – the presidency of this year’s climate summit.“China has only ever been in defence when it comes to climate change, but today’s announcement is the first step for its more active role. For success in Paris, however, all players – including China and the EU – need to up their game,” said Li Shuo, climate analyst for Greenpeace China.With China’s announcement, the world’s top polluters – China, the US and the EU – have now all tabled their climate plans ahead of the global climate conference taking place in Paris at the end of the year.
“Today’s pledge must be seen as only the starting point for much more ambitious action. It does not fully reflect the significant energy transition that is already taking place in China. Given the dramatic fall in coal consumption, robust renewable energy uptake, and the urgent need to address air pollution, we believe the country can go well beyond what it has proposed today,” added Li Shuo. China’s current carbon intensity target requires a reduction of CO2 emissions per unit of GDP by 40-45% by 2020, based on 2005 levels. Assuming China delivers 45% by 2020, a 65% and 60% carbon intensity reduction will mean 4.4% and 3.1% annual carbon intensity decrease respectively between 2020 and 2030. Achieving 45% carbon intensity reduction by 2020 would mean annual carbon intensity reduction of 3.9%.

Posted in Estero/world news, Spazio aperto/open space | Contrassegnato da tag: , , , | Leave a Comment »

Evolving Enterprise Applications

Posted by fidest press agency su martedì, 14 luglio 2009

London. When capital is in short supply the pressure to optimise existing resources and assets intensifies. In the IT space, enterprise applications such as enterprise resource planning (ERP) and customer relationship management (CRM) are prime targets. A new report by Europe’s leading IT research and advisory organisation Butler Group, points to the strategic importance of these applications in terms of running businesses efficiently and effectively, and how changes in the way they are architected, delivered, and used are altering the entire application value proposition and lifecycle. Titled “Evolving Enterprise Applications”, the report says there is a tendency to focus on cutting costs. It argues that cost reduction and value generation are two sides of the same bottom line so should be tackled together as part of a unified strategy with savings in one area being used to fund smart investments in another.  Technology changes such as the move to service oriented architecture (SOA) that brings modularity and therefore technical and business agility, increased use of business process management (BPM) capabilities to enable enterprise-wide process standardisation, embedded business intelligence (BI) for actionable insight, and participatory Web 2.0-type technologies for collaboration and real time interaction, all play a part in opening enterprise applications up, changing the way they are used, and enabling them to be used for more. Each technology would be so much less without the enterprise application DNA structure. However, for this transformation to be effective, closer alignment between business and IT is a prerequisite. Maintaining the value of existing assets can be achieved through internal optimisation – opting for standardization over customisation, general license and user housekeeping, upgrade and maintenance strategies, and so on – which in addition to reducing operational costs will improve operational efficiency with minimal investment and prevent investments falling into the application equivalent of negative equity. Yet, strategic investment in application extensions at the micro level is also a requirement: for example investing in functionality that reduces waste in production planning by a few percentage points can deliver substantial direct financial returns. “Existing implementations are the perfect platform to deliver these sorts of micro-based incremental benefits, rapidly, with minimal risk and in a cost efficient manner,” says Eager. The economic climate has highlighted the need for business agility and as agility is ultimately enabled by the supporting IT and application infrastructure, the situation is playing well to the Software-as-a-Service (SaaS) movement. This alternative delivery method offers flexibility and cost efficiency, providing the essentials to enable organisations to bring about change in the way they carry out their business. With the advent of development platforms SaaS no longer means having to take what you are given, and with an architecture built for the Web and for integration, it provides a valuable adjunct toorganisations looking for application technology to support business

Posted in Economia/Economy/finance/business/technology, Estero/world news | Contrassegnato da tag: , , , | Leave a Comment »

Child deaths drop sharply

Posted by fidest press agency su venerdì, 22 Mag 2009

Geneva  Deaths  of children aged under five years have dropped by 27% globally since 1990, according to the latest World Health Organization (WHO) estimates. But in WHO’s first progress report on the health Millennium Development Goals (MDGs) released today in the World Health Statistics 2009, other results are mixed.  An estimated 9 million children aged under five years died in 2007, significantly fewer than the 12.5 million estimated to have died in 1990, the baseline year against which progress towards the goals is measured. However, in many African countries and in low-income countries generally, progress has been insufficient to reach the MDG target, that aims for a two thirds reduction in child mortality by the year 2015. World Health Statistics 2009 is an annual report based on more than 100 health indicators collected from WHO’s 193 Member States. These indicators provide a snapshot of global health trends. However, the data have some limitations. These are explained in our Frequently Asked Questions about health statistics. More information about WHO’s health statistics can be found

Posted in Diritti/Human rights, Estero/world news | Contrassegnato da tag: , , , | Leave a Comment »