Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 31 n° 301

Posts Tagged ‘survival’

SOTIO’s DCVAC/LuCa Significantly Improves Survival in Patients with Stage IV Non-small Cell Lung Cancer

Posted by fidest press agency su martedì, 4 giugno 2019

SOTIO, a biotechnology company owned by the PPF Group, presented new statistically and clinically significant results from its Phase I/II clinical trial evaluating DCVAC/LuCa, an active cellular immunotherapy product, in patients with stage IV non-small cell lung cancer. The final analysis of the data confirmed the promising clinical efficacy of DCVAC/LuCa. SLU01 clinical trial results were presented by the principal investigator Libor Havel, MD, from Thomayer University Hospital in Prague (Czech Republic) at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago today.
SOTIO evaluated its proprietary product DCVAC/LuCa in an open label, randomized, multicenter Phase I/II trial in combination with carboplatin/paclitaxel in patients with advanced or metastatic non-small cell lung cancer. Patients that received DCVAC in combination with chemotherapy have a 46% lower risk of dying compared to those who received chemotherapy alone. Furthermore, the 3.7-month longer survival with the DCVAC/chemo combination is statistically and clinically significant. Treatment was very well tolerated and there were no serious adverse events solely related to DCVAC/LuCa.

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Italian law must change to improve survival from cardiac arrest

Posted by fidest press agency su martedì, 6 marzo 2018

Milan (Italy) An Italian law requiring citizens to hold a certificate to use a defibrillator must change to improve survival from cardiac arrest, researchers argued today at Acute Cardiovascular Care 2018, a European Society of Cardiology congress. “Automated external defibrillator (AED) use before the arrival of the emergency medical services (EMS) plays a key role in improving victim survival from out-of-hospital cardiac arrest,” said lead author Dr Enrico Baldi, resident physician in cardiology at IRCCS Policlinico San Matteo, Pavia, Italy.The study included two separate analyses – the first to assess how many times AEDs are used when people have an out-of-hospital cardiac arrest witnessed by a bystander in Pavia Province and the second to assess the impact on survival of the use of AEDs by a layperson before the arrival of the EMS.The study used the Pavia Cardiac Arrest Registry (Pavia CARe), which was set up in October 2014 and enrols all out-of-hospital cardiac arrest patients in the province. All patients enrolled in the Registry up to March 2017 were included, with the exception of those whose cardiac arrest was witnessed by EMS.The researchers calculated the rate of AED use before EMS arrival in the patients whose cardiac arrest was witnessed by a layperson and whose first heart rhythm was shockable.2 An AED was used by a layperson in just 9 out of 140 patients (6.4%).“This is an extremely low rate of AED use,” said Dr Baldi. “In countries where the ‘Good Samaritan’ law is in place and all citizens can use an AED, the rate of AED use before EMS arrival is around 15–20%.” The second analysis was conducted in patients who received bystander defibrillation and had a shockable rhythm. This group of patients also included those where the cardiac arrest itself had not been witnessed. A total of 10 patients in this analysis received the first shock by a layperson before EMS arrival. The researchers compared the survival of those 10 patients and the 99 patients who received the first shock by EMS. The two groups were similar in terms of age and sex. The rate of survival at 30 days was significantly higher in the patients with defibrillation provided by bystanders (60%) compared to those with defibrillation by EMS (24%) (p=0.02). The time from cardiac arrest to the first shock was significantly shorter in the group receiving defibrillation by bystanders (5 minutes) compared to those receiving defibrillation by EMS (12 minutes) (p<0.01). “These results confirm the positive impact on survival of AED use before the arrival of EMS,” said Dr Baldi. “It is crucial to act quickly in cardiac arrest and bystanders can be instrumental in determining whether a patient lives or dies.” “The Italian law requiring people to be certified in the use of AEDs is a major limitation on their use by members of the public,” he added. “There is no shortage of defibrillators – there are 503 AEDs in public places in Pavia Province, which amounts to one for every 1,093 residents.”
In addition to the legal challenge, another factor that contributes to the low rate of AED use in Italy compared to some other parts of Europe is that there is currently no system to alert people nearby who may be able to assist when someone has had a cardiac arrest – such as phone apps that are used in some countries – or to automatically alert the fire brigade and police that a cardiac arrest has occurred. If they are nearby, these emergency services, who carry AEDs and are trained in their use, could arrive more quickly than the EMS.Dr Baldi said: “Italian law should be urgently reviewed to allow all citizens to use an AED regardless of whether they have been trained. We also need to create systems to alert nearby citizens and the fire brigade and police that someone has suffered a cardiac arrest. Every moment is critical in these cases. Just three or four minutes can make the difference between life and death.”

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Heart attack patients prescribed antidepressants have worse one-year survival

Posted by fidest press agency su lunedì, 5 marzo 2018

The observational study of nearly 9,000 patients found that those prescribed antidepressants at discharge from hospital after a heart attack had a 66% greater risk of mortality one year later than patients not prescribed the drugs, although they noted the cause is not necessarily related directly to the antidepressants.Lead author Ms Nadia Fehr, a medical student at the University of Zurich, Switzerland, said: “Previous studies have suggested that cardiovascular disease may increase the likelihood of being depressed. On the other hand, depression appears to increase the probability of developing cardiovascular risk factors. However, little is known about the impact of depression on outcome after a heart attack.”This study assessed the association of antidepressant prescription at hospital discharge with the one-year outcomes of patients with acute myocardial infarction (heart attack).Data from AMIS Plus, the Swiss nationwide registry for acute myocardial infarction, were used to analyse 8,911 heart attack patients admitted to hospitals in Switzerland between March 2005 and August 2016. Patients were followed up by telephone 12 months after discharge.The researchers compared patients who received antidepressant medication at discharge with those who did not with regard to baseline characteristics and one-year outcomes including mortality, a subsequent heart attack, and stroke.A total of 565 (6.3%) patients received antidepressants at discharge from hospital. Compared to those who did not receive the drugs, patients prescribed antidepressants were predominantly female, older, and more likely to have hypertension, diabetes, dyslipidaemia, obesity and comorbidities. They were less likely to undergo percutaneous coronary intervention or receive P2Y12 blockers or statins, and stayed in hospital longer.After adjusting for baseline characteristics the researchers found that the rates of stroke and subsequent heart attacks were similar between the two groups, but patients prescribed antidepressants had significantly worse survival. The rate of all-cause mortality at one-year after discharge was 7.4% in patients prescribed antidepressants compared to 3.4% for those not prescribed antidepressants (p<0.001).Antidepressant prescription was an independent predictor for mortality, and increased the odds by 66% (odds ratio: 1.66; 95% confidence interval: 1.16 to 2.39).“This was an observational study so we cannot conclude that antidepressants caused the higher death rate,” noted Ms Fehr.She concluded: “Our study showed that many patients are treated with antidepressants after a heart attack. More research is needed to pinpoint the causes and underlying pathological mechanisms for the higher mortality we observed in this patient group.”

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Fiat plays double or quits with Chrysler

Posted by fidest press agency su venerdì, 26 novembre 2010

Anticipazioni del numero di The Economist che è in edicola questo fine settimana. Gli argomenti trattati sono diversi. Quello che abbiamo stralciato per i nostri lettori è l’articolo sulla: Fiat plays double or quits with Chrysler – Sergio Marchionne reckons that Chrysler can help save Fiat from itself and from Italy. It is a gamble, but one he has to take. Ve lo proponiamo in lingua originale. Gli altri servizi riguardano:
L’ editoriale sulla crisi dell’euro: Spreading from Ireland to Iberia – To stop the euro’s meltdown Spain, above all, must rediscover its reformist zeal.
L ‘ analisi sulle critiche sulla manovra di Quantitave Easing da parte della Fed: Fed under fire – Political attacks on America’s central bank are misguided
Mentre nella sezione Europe:-   La rubrica Charlemagne:  Europe and America – To Americans, Europe means NATO – but they should think of the European Union too
Sergio Marchionne reckons that Chrysler can help save Fiat from itself and from Italy. It is a gamble, but one he has to take al rm, even though for some years much of its production and most of its carmaking prots have come from South America. Fiat’s joint venture in Russia with Sollers is set to become the second-largest carmaker in that growing market. The Fiat 500s sold across Europe are made in Poland, and those about to go on sale in America will come from a Chrysler factory in Mexico. As Mr Marchionne puts it, We’re a global octopus now. That means Fiat-Chrysler has the means to move production wherever it is cheapest. This is a good job: the productivity gap between Fiat’s Italian factories and its for- eign operations is astounding. In Italy, 22,000 workers spread across ve assembly plants make about 650,000 cars a year. In Fiat’s huge Brazilian factory, just 9,400 workers turn out around 750,000 cars; and its Polish plant does even better, with 6,100 workers turning out 600,000 cars. Chrysler is somewhere between these extremes: it has 50,000 workers (whose numbers include those making engines and gearboxes, unlike Fiat’s) in ten factories in America, Canada and Mexico turning out 1.6m cars.
Mr Marchionne recently denied having any plans to stop making cars in Italy. For along time, that would have been unthink- able anyway. But Fiat no longer dominates its home market as it used toits share in It- aly is less than one-third, having long been more than half. Although an abrupt pullout from Italy remains unlikely, it is now easy to imagine Fiat leaving its plants there
to wither while pumping investment into countries where sales growth and produc- tivity are much higher.  We are losing money in Italy. We can’t go on losing money like this, says Mr Marchionne. He describes how Fiat’s plants there are hobbled by rigid work practices, rampant absenteeism and lightning strikes that mean about one in three workers down tools on any given day. He has slimmed the factories and avoided mass closures. He is now promising a doubling of production in Italy, to meet expected demand resulting from the Chrysler merger but only on his terms. In return for investment to increase production, he is insisting on tearing up national wage deals and replacing them with factory-level agree- ments that provide more exible working to t peaks and troughs in demand. Whether the Italian plants will march Mr Marchionne’s way, or the highway, is so far unclear. When he announced plans to transfer production of the Panda (300,000 a year) from Poland to a factory near Naples, sustaining the 5,000 jobs there, some workers at rst spurned this opportunity because they would have to make a downmarket model as well as the posher Alfa
Romeos they currently turn out (at a rate of just 30,000 a year). Mr Marchionne feels he is winning the argument with most workers but, he says, a group of leftists, amounting to around one-eighth of the workforce, is bent on disruption. Such bloody-mindedness is reminiscent of the death throes of British Leyland in the early 1980s. Mr Marchionne may now be at his Thatcher moment, in which he loses patience and gets tough. Given Fiat’s weakness in its home market and the obstinacy of some workers there, its boss is sure that it is worth running all the risks involved in merging with Chrysler and re-entering the American market. Indeed, these bold steps may be the only guarantee of its survival.

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Editoriale. Berlusconi: The survival

Posted by fidest press agency su venerdì, 19 novembre 2010

Abbiamo rilanciato il servizio in inglese del settimanale “The Economist” dove, tra l’altro, fa il punto sulla crisi politica in atto in Italia. Il titolo del pezzo è: “The secret of an unknown prime minister’s servival”. E’ interessante non tanto considerare quanto ci dice l’articolista quanto capire le perplessità di chi deve contemperare due esigenze: quella di riportare una notizia e renderla, in pari tempo, intellegibile ai lettori di un’area europea, e anglosassone nello specifico, pochi abituati ad avere una chiave di lettura così insolita sulla politica in Italia. Se stiamo alle cronache rosa dobbiamo considerare un presidente del Consiglio che nella sua villa di Arcore affoga la solitudine di uomo separato dalla moglie servendosi di giovani prostitute, pardon escort, secondo il lessico di una certa letteratura per questo tipo di donne di “alto bordo”. E ne fa un amore mercenario. Se stiamo al critico Fini, già compagno, per anni, di avventure “politiche”, è tempo che Berlusconi faccia le valige e tolga il disturbo. Per l’opposizione è il “maestro” degli inganni, delle promesse, degli annunci e il suo solo assillo non è governare ma sfuggire alla scure della giustizia con decine di processi che lo attendono. Nello stesso tempo i supporter del Presidente fanno osservare che per anni è stato letteralmente ricoperto di fango: scandali sessuali, intrighi politici, affari poco chiari e quanto altro e tutte le volte gli italiani nel segreto delle urne lo hanno sostenuto permettendogli di vincere le elezioni e di scornare gli avversari. E allora? Vuol dire che gli italiani nel loro intimo parteggiano per chi trasgredisce le regole, si fa beffa della morale, li illude con promesse che tutti sanno non potrà realizzare e lo preferiscono alle Cassandre di turno che preannunciano sventure di ogni genere e, magari, possono avere anche ragione. A questo punto dobbiamo considerare di che pasta è fatto questo elettore italiano così disinibito, così trasgressivo, così fatalista nel godere oggi senza pensare al futuro e che riversa nell’urna la sua voglia di restituire alle ipocrisie della politica pan con focaccia offrendogli il suo miglior prodotto. E’ che questo tanto decantato “popolo sovrano” che si scopre sempre di più poco “popolo” e un risibile “sovrano” ha chiara la consapevolezza che in questo marasma politico, in questo surreale modo di ragionare sul sesso degli angeli, se vi è un uomo capace di tenere in qualche modo uniti questi cocci nazionali è proprio lui, sia pure con tutti i suoi difetti: Silvio Berlusconi. Vi immaginate cosa succederebbe se rinunciasse alla sua leadership? Dov’è chi potrà sostituirlo? Forse Fini o Casini? Forse Bersani o Rutelli, o D’Alema o Tremonti? No. Assolutamente no. Oggi sono uniti solo per accreditarsi un posto in prima fila per la successione ma sarebbero pronti a dividersi un minuto dopo. E’ amaro dirlo ma è la verità: dopo Berlusconi ritorneremo alla cartina di tornasole della ingovernabilità e dei governi balneari. Sono questi gli italiani che per costruire qualcosa non rafforzano il partito in cui militano ma pensano solo a farsene uno per conto proprio. (Riccardo Alfonso

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Global climate protests

Posted by fidest press agency su sabato, 12 dicembre 2009

Copenhagen. Half-way through the critical UN Climate Change Conference in Copenhagen —  where delegates and world leaders are negotiating the future of the planet — more than 500 civil society groups  supported  the ‘Real Deal Global Day of Action’ event  demanding a fair, ambitious and legally binding treaty to avert catastrophic climate change. In Copenhagen, Greenpeace volunteers from 32 countries along with thousands other protestors peacefully marched from Christiansborg Slotsplads at the Danish Parliament to the Bella Center where the UN climate summit is taking place to urge world leaders to show far greater political courage and commitment to tackling climate change. The protestors will deliver seventeen giant ship sails bearing climate messages and images to Yvo de Boer, Executive Secretary of the United Nations Framework Convention on Climate Change in the ‘Climate Rescue Station’ at Bella Center. The march will culminate in a candlelight vigil at the UN summit tonight. Earlier today in Australia, about 80,000 people took part in a ‘walk against warming’, while in Hong Kong, about a thousand people participated in a 3-legged walk. In Beijing drums, historically used in China to sound the time, were played at the Yongdimen gate to remind leaders that time to reach a fair, ambitious and legally binding climate deal is running out. Despite some key industrialised countries lowering expectations for a deal in Copenhagen, the first week of the talks has been dominated by a determined push for a legally binding agreement by developing countries which are literally fighting for their survival.

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