Fidest – Agenzia giornalistica/press agency

Quotidiano di informazione – Anno 33 n° 335

Posts Tagged ‘targets’

Paris turning point: net zero targets would bring warming to 2.1degC

Posted by fidest press agency su sabato, 5 dicembre 2020

If all national governments meet their 2050 net zero emissions targets, warming could be as low as 2.1˚C by 2100, putting the Paris Agreement’s 1.5˚C limit within striking distance, according to new calculations by the Climate Action Tracker.However, all eyes are now on their 2030 Paris Agreement targets, all of which need to be considerably strengthened to get national emissions onto a net zero pathway.The CAT’s new modelling takes into account announcements by China, President-elect Biden’s 2050 net zero target for the US, along with other recent net zero announcements. In total, 127 countries, responsible for around 63% of emissions are considering – or have adopted, net zero targets.“Five years on, it’s clear the Paris Agreement is driving climate action,” said Prof Niklas Höhne of NewClimate Institute, a Climate Action Tracker partner organisation. “The Paris Agreement introduced the goal of global net zero greenhouse gas emissions, and now we’re seeing a wave of countries signing up to it. Can anyone really afford to miss catching this wave?”“Not only is our warming projection for government climate pledges falling to just over two degrees, a level that puts the Paris Agreement 1.5˚C target within reach, but we’re also seeing a drop in projections for real world action.”The CAT’s warming projection of its ‘current policies’ scenario has fallen from 3.6˚C in 2015 to 2.9˚C today. This drop has come from governments implementing new policies, increased use of renewable energy, a downturn in the use of coal, and lower economic growth assumptions (both prior to and because of the pandemic). However, while 2050 pledges are welcome, none of the big emitters have strengthened their 2030 Paris Agreement targets (nationally determined contributions or NDCs) in time for this year’s deadline set by the UNFCCC.

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Deutsche Bank sets itself ambitious sustainability targets

Posted by fidest press agency su mercoledì, 20 Maggio 2020

Deutsche Bank (XETRA: DBKGn.DB / NYSE: DB) has for the first time published quantifiable targets for expanding its sustainable business activities covering the ESG (environmental, social, governance) space and aims to support the transformation towards a sustainable economy. By the end of 2025, the bank will increase its volume of ESG financing plus its portfolio of sustainable investments under management to over 200 billion euros in total. “We are driven by a very strong conviction to help shape the global change to a sustainable, climate-neutral and social economy,” says Deutsche Bank CEO Christian Sewing. “The target of 200 billion euros in sustainable financing and ESG investments is ambitious compared to our peers. However, we are starting from a good base because, as a globally active financing house, we can serve the growing demand of our clients for sustainable investment products by ourselves.” The minimum volume of 200 billion euros within six years includes loans granted by 2025 and bonds placed by Deutsche Bank during this period. It also includes sustainable assets managed by the Private Bank as of the end of 2025. Deutsche Bank is thereby following the standards used in the industry. The ESG assets of around 70 billion euros managed by asset manager DWS as of the end of 2019 are not included in these calculations. When defining which activities it will classify as sustainable, the bank will be guided by the EU Taxonomy – the European Union’s ESG standard. In areas where the EU has yet to develop its own standards, Deutsche Bank will rely on its own transparent criteria. The bank will report annually on the progress towards achieving this target in its Non-Financial Report. It will also disclose more details on its definition of sustainable finance by the end of the second quarter 2020.

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International Conference on Molecular Targets and Cancer Therapeutics

Posted by fidest press agency su domenica, 27 ottobre 2019

Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for cancer, today announced that the company will participate in the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2019 in Boston, October 27-30, including a poster presentation on October 27th.The poster presentation, titled “A comprehensive, highly accurate genomics platform for precision immunotherapy: Simultaneously characterize tumors and the TME from a single FFPE sample,” will describe the Personalis universal cancer immunogenomics platform, ImmunoID NeXT™. The poster will provide an overview of how the platform can be used to explore critical immunotherapy-related biomarkers of resistance and response; utilizing analytics including: human leukocyte antigen (HLA) typing and HLA loss of heterozygosity (LOH), neoantigen prediction and load, immune repertoire characterization, oncoviral detection, immune cell deconvolution, as well as the evaluation of tumor mutational burden (TMB) and microsatellite instability (MSI) status.ImmunoID NeXT™ is the first platform to enable comprehensive analysis of both a tumor and its immune microenvironment from a single sample. The platform can be used to investigate the key tumor- and immune-related areas of cancer biology, consolidating multiple oncology biomarker assays into one and maximizing the biological information that can be generated from a precious tumor specimen. The presentation will be delivered by Robert Power, M.S., Product Manager.

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The EU will not reach 2050 climate neutrality without raising its energy and climate targets

Posted by fidest press agency su mercoledì, 16 ottobre 2019

Members adopted the opinion ‘Sustainable Europe by 2030, follow-up to the UN Sustainable Development Goals: ecological transition and the Paris Agreement on Climate Change’. The opinion focuses on the ‘planet’ pillar of the UN’s 2030 Agenda – the goals linked to the ecological and climate transition. Members stress the urgent need to ‘localise’ SDGs including the definition of local and regional objectives, milestones and progress indicators in addition to deploying adequate resources.Rapporteur Sirpa Hertell (FI/EPP), city councillor of Espoo, said: “We can achieve the Sustainable Development Goals only if the EU and national levels work together with cities and regions. It is us who can transform these goals locally through sustainable projects. This is what we have done successfully in my city of Espoo.” It is estimated that 65% of the 169 targets underlying the 17 SDGs will not be reached without the engagement of local and regional governments (OECD).As requisites to achieve the SDGs, members request full policy coherence and effective multi-level governance – which formally includes LRAs in planning, implementation, monitoring, reporting and verification at the EU and global levels. Ending subsidies on fossil fuels and strong market-based incentives for multiplying clean investments are a must, members agree. During the new mandate 2019-20124, the CoR seeks to deepen cooperation with the European Parliament’s Intergroup on Climate Change, Biodiversity and Sustainable Development and EP competent committees to accelerate the implementation of SDGs locally.
The CoR calls on Member States to further involve local and regional authorities in the definition and future implementation of their NECPs as stipulated in the Regulation on the governance of the energy union and climate action. In addition, the EU’s Assembly of cities and regions proposes to create and coordinate, jointly with the European Commission, a permanent platform that brings together Member States’ representatives, local and regional authorities and CoR members as to improve cooperation and coherence towards reaching the EU’s 2030 climate and energy objectives and climate neutrality by 2050.Members adopted an opinion on ‘Implementing the Paris Agreement through innovative and sustainable energy transition at regional and local level’. Rapporteur Witold Stepien (PL/EPP), Member of the Lódzkie Regional Assembly, said: “To implement the Paris climate accord and ambitious emission targets for climate protection, we need a just energy transition. For this to succeed, it is necessary to broadly involve regional and local authorities as they can most effectively put into practice and stimulate the initiatives and expectations of citizens and businesses.”The CoR recalls its demand to increase the EU’s 2030 target of reducing greenhouse gas emissions (GHG) from 40% to 50%, to raise the renewable energy target to 40% and to set more ambitious targets for energy efficiency as the only way to reach climate neutrality by 2050.Complementing the opinion of rapporteur Stepien, members adopted ‘The socio-economic transformation of Europe’s coal regions’ by Mark Speich (DE/EPP), Secretary of State for Federal, European and International Affairs from North Rhine Westphalia. Members agree on the need to deploy a dedicated fund to support coal regions’ economic transformation and alleviate the socio-economic difficulties that may result from it. While linked to cohesion policy governance, the specific fund should not be deducted from its current budget share, members agree.The clean energy transition in coal and energy-intense regions is a key aspect of Europe’s decarbonisation and a requisite to honour the EU’s commitments under the Paris climate agreement. Coal accounts for nearly a quarter of the total electricity production in the EU. It employs 240,000 people in mines and power plants across 41 regions and 12 EU countries (EC). Members unanimously adopted the opinion ‘Smart cities: new challenges for a just transition toward climate neutrality – how to implement the SDGs in real life’. Rapporteur Andries Gryffroy (BE/EA), member of the Flemish Parliament, said: “Cities and communities have an important role to play in the transition to a resource-efficient, climate-neutral and bio-diverse Europe. We need to create more and better opportunities to help and support local and regional actors in this evolution. A bottom-up approach, with smart actions evolving out of local cooperation will be necessary. This inclusivity is equally necessary to close the digital gap as to make sure that the weakest parties are not left behind in the transition towards a digital society.” The adopted opinion responds to a referral of Finland’s EU presidency.

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Collaboration Aims to Discover New Immuno-oncology Targets

Posted by fidest press agency su mercoledì, 14 agosto 2019

Harvard University and Merck are launching a collaboration that will provide significant research funding for up to four years to support immuno-oncology research led by Arlene Sharpe, MD, PhD, at Harvard Medical School (HMS). Sharpe, the George Fabyan Professor of Comparative Pathology and chair of the HMS Department of Immunology, will collaborate with researchers at Merck on a major project aiming to discover novel aspects of the immune system that may be targeted in future treatments for cancer.“This collaborative project aims to discover and validate novel regulators of immune responses,” said Dr. Sharpe. “Immunotherapies such as checkpoint inhibitors have revolutionized the treatment of cancer, but my lab is deeply interested in understanding why some patients do not respond or develop resistance to those interventions. My hope is that by defining mechanisms that inhibit immune responses to tumors, we will identify very important druggable targets and new approaches to improve cancer immunotherapy.”The funding will support the work of scientists in the lab of Dr. Sharpe, who is a renowned leader in the field of tumor immunology. She is a member of the National Academy of Sciences and the National Academy of Medicine, and the recipient of numerous awards including the Warren Alpert Foundation Prize in 2017 for her contributions to the discovery of the PD-1 pathway.Under the agreement spearheaded by Harvard’s Office of Technology Development, Merck will have the option to negotiate an exclusive license to innovations arising from the research collaboration to develop these discoveries toward potential treatments for patients.“Collaboration with leading scientific groups is an integral part of Merck’s discovery strategy,” said Dr. Nick Haining, vice president for oncology discovery at Merck Research Laboratories. “We look forward to working with Dr. Sharpe’s team to investigate new ways to harness the immune system for therapeutic advances.”

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Statin side effects are strongest predictor of failure to meet cholesterol targets

Posted by fidest press agency su sabato, 18 febbraio 2017

cardiologiaSophia Antipolis. Statin side effects are the strongest predictor of failure to meet low-density lipoprotein (LDL) cholesterol targets, according to research published today in the European Journal of Preventive Cardiology.1 Other predictors were statin non-adherence and use of weaker statins.“The beneficial effect of reducing LDL cholesterol on slowing the progression of coronary heart disease is overwhelmingly documented today in epidemiologic and randomised controlled studies,” said lead author Dr John Munkhaugen, a cardiology trainee and post-doctoral researcher at Drammen Hospital, Norway.“European guidelines2 recommend a blood LDL cholesterol goal of less than 1.8 mmol/l but just one in five cardiac patients taking lipid-lowering drugs achieve this,”3 he added.The NORwegian COR (NOR-COR) prevention project originates from the Department of Medicine at Drammen Hospital and is a collaboration between Drammen and Vestfold hospitals, and the Department of Behavioural Sciences in Medicine and Institute of Clinical Medicine, University of Oslo. It is investigating why patients fail to control risk factors including lipids and blood pressure after they have a cardiovascular event. This analysis examined the reasons why cardiac patients do not achieve the LDL cholesterol target.The study included 1,095 patients hospitalised with a first or recurrent coronary event or treatment (heart attack, coronary artery bypass graft, or coronary stent) who were identified from medical records at two Norwegian hospitals (Drammen and Vestfold). Sociodemographic, medical and psychosocial information was collected from medical records, an interdisciplinary self-report questionnaire, clinical examinations, and blood samples while patients were in hospital and at follow-up after two to 36 months.
The researchers found that 57% of patients were not meeting the LDL target of 1.8 mmol/l at follow-up. Statin specific side effects (mainly muscle complaints), low statin adherence, and moderate- or low-intensity statin therapy were the main reasons for failing to meet the target.Patients with side effects were more than three times more likely to miss the cholesterol target than those without side effects. Those who did not take their statins were three times more likely to miss the target than patients who did take them. Patients prescribed moderate- or low-intensity statins were 62% more likely to miss the target than those prescribed high-intensity statins.“We found the same three reasons for not meeting the target when LDL was analysed as a dichotomous or continous variable which confirms the strength of the associations,” said Dr Munkhaugen. “Surprisingly, low socioeconomic status and psychosocial factors did not predict failure to control LDL cholesterol.” “The findings show that the focus for interventions to improve LDL cholesterol control are statin side effects, and adherence to and prescription of sufficiently potent statins,” he continued.Dr Munkhaugen said more research was needed on why side effects of statins had such a big effect on meeting cholesterol goals. “Patients who experience side effects are probably more likely to reduce or terminate statin use, or their doctor may prescribe a weaker drug or take them off statins altogether,” he said. “Individual variations in how the body reacts to and uses the drug may also play a role.”The links between non-adherence and intensity of statin therapy on LDL cholesterol are likely explained by the pharmacological effects of the drug. “Not taking the prescribed amount of statins or being prescribed a weaker statin means there is less drug in the body to act and lower LDL,” said Dr Munkhaugen.“The reasons for statin non-adherence are a complex interaction between factors related to the patient and the healthcare system,” he added. “Interventions aiming to improve statin adherence have been a priority in recent years, but the success has been modest and short-lived.”
The study found that the use of high-intensity statins was significantly more frequent in patients who achieved the cholesterol target. But Dr Munkhaugen said: “The relationship with adherence and side effects needs to be clarified before advice can be given about the potency of statins that should be prescribed. Our findings point to the need for more research on ways to ensure adherence and prescription of sufficiently potent statins, while at the same time addressing side effects.”

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Snam – Presentazione Strategy & Targets 2012-2015

Posted by fidest press agency su domenica, 11 marzo 2012

Si terrà martedì 13 marzo alle ore 15 presso gli headquarters di Snam, a San Donato Milanese, la presentazione da parte dell’Amministratore Delegato, Carlo Malacarne, del piano strategico 2012-2015. La presentazione sarà l’occasione per comunicare nel dettaglio gli investimenti e gli obiettivi della Società per il quadriennio dal 2012 al 2015, finalizzati allo sviluppo del sistema italiano delle infrastrutture del gas e all’espansione all’estero, con l’obiettivo di contribuire a fare dell’Italia un hub del gas per il Sud Europa. Nei prossimi anni per il mercato del gas si prevede una crescita progressiva della domanda, accompagnata dalla necessità di avere maggiori garanzie per la sicurezza degli approvvigionamenti e la flessibilità del sistema. Snam è oggi nelle condizioni di cogliere le opportunità connesse all’attuazione del Terzo Pacchetto Energia Ue e realizzare le condizioni per la creazione di un “gas-hub” per il sud Europa che permetta di trasformare l’Italia da Paese consumatore a sistema di transito del gas, data la sua strategica posizione geografica che la vede un crocevia naturale dei principali flussi di gas dai Paesi produttori ai Paesi consumatori.
L’evento Snam-Strategy & Targets 2012-2015 sarà trasmesso in video webcast su http://www.snam.it dove saranno disponibili anche i materiali utilizzati per la presentazione.

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“Lipstick” cigarette packages woo young women

Posted by fidest press agency su venerdì, 8 luglio 2011

The new WHO report on the global tobacco epidemic reveals that only 13 out of 53 countries in the WHO European Region, most of them in the European Union, require cigarette packets to carry pictorial warnings about the dangers of smoking, and most of these graphic images cover less than half of the package. Of the remaining 40 countries, 27 stipulate that packets carry warnings of various kinds, but graphic images are not yet required, and the others call for weaker warnings. No country in the Region uses large and clear health warnings, on the front and back of packets, that highlight specific illnesses, as agreed in the WHO Framework Convention on Tobacco Control (FCTC). The tobacco industry specifically targets girls and young women through appealing pack designs. Countries increasingly restrict and ban conventional tobacco advertising: over 81% of those in the European Region ban advertising, promotion and sponsorship. The tobacco industry circumvents these bans by investing heavily in less traditional forms of promotion, such as using the packet itself as advertising.
The industry has identified women and girls as a highly viable market, and recently used new product designs, such as tobacco packages that resemble lipsticks. Social and cultural constraints are weakening, and tobacco use by females has become acceptable, and possibly even glamorous. Female spending power is increasing, and the industry’s false portrayal of smoking as a symbol of empowerment has indisputable impact.
The evidence shows that effective health warnings, especially those that include pictures, motivate users to quit and reduce the appeal of tobacco to people who are not yet addicted. Yet only close to 39% of the population in the WHO European Region lives in countries that require such warnings on tobacco packaging. Tobacco is the single most preventable cause of death in the world. This year, it will kill nearly 6 million people: more than tuberculosis, HIV/AIDS and malaria combined. Other key findings from the report include:
23% of the population in the Region (207 448 988 people) is protected by comprehensive national legislation banning smoking in public places;
19% of countries still allow smoking in hospitals and schools; and
62% of countries offer national toll-free quitlines, although 1 does not offer any support to quit tobacco use.
In addition, the WHO European Region excels in tobacco taxation. Of the 27 countries and territories in the world with the highest tobacco taxes, 22 countries are in the Region, and 42% of European countries have tobacco taxes that make up more than 75% of the retail price. On average, tax comprises 75% of the retail price in high-income countries, and 51% in low- and middle-income countries. Ireland has the most expensive price for a twenty-piece pack of the best-selling and the cheapest brands. Kazakhstan has the lowest price for the best-selling brand and the Republic of Moldova has the lowest price for the cheapest brand. The WHO headquarters web site offers further information, including both the WHO report on the global tobacco epidemic (http://www.who.int/tobacco/global_report/2011) and the WHO FCTC (http://www.who.int/fctc/en).

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